这是一个会有实质性突破的时候，你要为此做好准备并等待。
This is when the real nitty gritty happens and you've got to be ready and waiting.
他说，本轮六方会谈各方在立场上还有分歧，会谈能否取得实质性突破要看各方态度。
He said that differences still exist in the stances of the six delegations on this round of Talks and whether substantive breakthrough can be made will depend on the attitude of all parties concerned.
目前我国在扩大消费(尤其是扩大农民消费)和财政减税方面并没有取得实质性突破和进展。
Currently in our country there is no substantial breakthrough and development in expanding consumption (especially for the farmers) and reducing finance tax.
自动制图综合是一国际性难题，国内外学者对其进行了多年研究，但普遍认为尚无实质性突破。
Automatic map Seneralization is an international difficult problem, many scholars have researched this problem for several years, but get no virtual improvement.
进入21世纪，我国经济增长方式转型已经取得了实质性突破，全要素贡献率达到了年均57.58%。
Stepping into 21st century, the economic growth mode transformation of China has made substantial progress. The TFP contribution rate has achieved 57.58% per year.
而长期以来，一直困惑自由曲面精加工取得实质性突破的关键问题之一，就是加工工具的运动位姿控制问题。
But for a long time, one of the key questions which puzzled free surface precision machining obtaining substantive breakthrough, is machining tool's movement pose control problems and so on.
过去由于受研究手段所限，对钢管连轧过程诸多问题，如金属流动、缺陷形成等的研究难以取得实质性突破。
As research methods limited, many problems such as metal flowing, defect forming have not been able to attain the significant breakthrough for steel tube con-rolling process.
就目前而言，这是一个术语上的而非实质性的突破。
For the moment, it is a breakthrough of terminology more than substance.
当然，奥巴马的出席不一定会给这些国际问题的解决带来什么实质性的突破。
Obama’s presence does not promise a sudden solution to the world’s problems.
结果造成物理学在很长时期内没有实质性的突破。
The result is that physics in a very long period of time has had no substantial breakthrough.
目前在对微观组织研究方面，组织模型能够完整建立，但是在应用上一直未能有实质性的突破。
Currently, though an organizational model can be completely built in research on the microstructure, there has not been a breakthrough in the application.
目前在对微观组织研究方面，组织模型能够完整建立，但是在应用上一直未能有实质性的突破。
Currently, though an organizational model can be completely built in research on the microstructure, there has not been a breakthrough in the application.
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