一旦你建立了你的健身计划，除非你的医生允许，否则不要做任何大的改变。
Once you have set up your fitness plan, don't make any great changes to it unless your doctor allows you to.
他们领会到这一难办之处，即任何大的改变都是充满压力的。
They appreciated the tricky point that any major change can be stressful.
为什么事情总是发生如此大的改变呢？
这么大的改变将会是极具破坏性的。
那将成为一次大的改变。
一些大的改变？
更进一步说，这些转变会给我们衡量新创业带来大的改变。
Further, these shifts could lead to a big change in how we evaluate startup companies.
不必然是大的改变。
不管是大的改变还是小的变化，总之就是要变一变。
Big changes or little ones it doesn't matter but a change none the less.
分析家指出，一个大的改变会首先在货币方面显示。
A major change would come on the monetary front, analysts said.
这一点小小的改变会给照片的整体效果带来非常大的改变。
That one little change can make a big difference in the overall look of your shot.
艾伦先生带来的一个大的改变可能就是他提高了财政预测的不确定性。
One big change that Sir Alan will introduce is highlighting the uncertainty of fiscal forecasts.
如此大的改变只应当在新的体系能够保障自身的优势时再做出。
And so large a change should be undertaken only for a system that can be defended on its own merits.
他以此作为今年参选的敲门砖，做出许多小承诺，但没有大的改变。
It is on that ticket that he has run this year, making many small pledges but no new big ones.
由JLR草拟的五年计划里面承诺不进行大的改变，由此塔塔获得了巨大的信任。
Tata was sufficiently convinced by the five-year plan drawn up by JLR that it has promised to back it without any big changes.
我相信是时机趋势所造成的，单是尧舜桀纣是没有办法造成那么大的改变。
I believed that the opportunity and trend caused it. Yao, or Shun, or Jie, or Zhou couldn't make so great changes alone.
药物制剂的批准和销售之后，生产散装的原料药方面可能会发生大的改变。
After approval and marketing of a pharmaceutical product, significant changes may be made in manufacturing the bulk drug substance.
赛车策略的魔法在不断演化，当规则出现大的改变时，则会出现显著的转变。
The black art of race strategy is constantly evolving, but goes through particularly marked transitions when major rule changes are introduced.
要想制定尊重这些事实的计划，各级管理部门就必须在对失败的看法上有一个大的改变。
Being able to make plans that respect these facts assumes a big change in how management at all levels thinks about failure.
做出大的改变。不然，它不值得花时间对待，而且通常最后会把你消磨殆尽。
Swing big. Otherwise, it's not worth people's time, and it usually ends up working out.
如果你想在处理自己的愤怒情绪上做出大的改变，就想一下你能从这些改变中获得什么吧。
If you want to make a big change in how you're handling your anger, think about what you'll gain from that change.
关掉电视，我们会发现自己与家庭成员间少了多少的交流，我们之间的关系发生了多么大的改变。
Since we've turned off the TV we've noticed big changes in ourselves and our interactions with our family members.
尽管银行方面声称他们接受提高安全缓冲的目标，但他们争辩道，任何大的改变都将阻碍经济增长。
Although they claim to accept the objective of raising safety buffers, Banks argue that any big changes will impede economic growth.
过去十年半的时间对你们的世界造成了相当大的改变，包括一系列即将导致的盛大转型。
The last decade and a half has wrought quite a change on your world, including a whole series of events that are about to result in a grand transformation.
我发现对我起作用的，是改变一下环境。不管是大的改变还是小的变化，总之就是要变一变。
What I have found to work for me is a change of scenery. Big changes or little ones it doesn't matter but a change none the less.
汉密尔顿掷地有声的话语惊醒了坐席上昏昏欲睡的人们，但从未登上头条，也没有引起大的改变。
Hamilton's words prompted vigorous nods of agreement across the aisle, but never made headlines or produced major changes.
汉密尔顿掷地有声的话语惊醒了坐席上昏昏欲睡的人们，但从未登上头条，也没有引起大的改变。
Hamilton's words prompted vigorous nods of agreement across the aisle, but never made headlines or produced major changes.
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