目的对合成的塞克硝唑进行结晶水的分析和稳定性研究。
OBJECTIVE To study the stability and crystal water of synthesizing secnidazole.
目的建立塞克硝唑注射液中细菌内毒素定量分析的方法。
OBJECTIVE to establish a method for monitoring bacterial endotoxins of secnidazole injection.
结论可用动态浊度法对塞克硝唑注射液中的细菌内毒素进行质量控制。
The results of sample test kept in line with that of the rabbit pyrogen test method to secn…
通过比较对塞克硝唑不同的合成路线，选择了一条适合工业化生产塞克硝唑的路线。
A route suitable for industrial production of secnidazole was improved, in which boron trifluoride etherate was used in replacing sulfuric acid as the catalyst.
塞克硝唑苯甲酸酯是塞克硝唑的前药，本文主要对塞克硝唑苯甲酸酯的药理活性进行研究。
Secnidazole benzoate is a former drug of secnidazole, this paper mainly study on the pharmacological activity of secnidazole benzoate.
通过对此过程的不同方法进行了对比，提出一条以环硫酸酯为N-羟基化试剂，并以塞克硝唑为例进行了合成。
By comparison of different approaches, a synthesis route was given, in which cyclic sulfate was used as N hydroxylalkylation reagent.
塞克硝唑片组实验室检查异常发生率为0.00%，替硝唑片组实验室检查异常发生率为2.08%，两组之间比较差异无统计学意义（P>0.05）。
The rates of abnormal results of laboratory test were 0.00% in trial group and 2.08% in control group. There were no significant differences between two groups in safety(P>0.05).
塞克硝唑片组实验室检查异常发生率为0.00%，替硝唑片组实验室检查异常发生率为2.08%，两组之间比较差异无统计学意义（P>0.05）。
The rates of abnormal results of laboratory test were 0.00% in trial group and 2.08% in control group. There were no significant differences between two groups in safety(P>0.05).
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