目的研究脆性组氨酸三聚体（FHIT） 基因异常转录与结肠癌的相关性。
Objective To study the relationship between aberrant FHIT transcription and colon carcinoma.
肝癌中存在FHIT基因高甲基化、转录异常、FHIT蛋白表达下降。
There exist hypermethylation, abnormal transcription of FHIT gene and down-regulation expression of FHIT protein in liver cancer.
文中主要综述了几十年来人们对DNA甲基化异常与基因转录及肿瘤发生之间关系的研究进展，尤其是最近的研究突破。
This article reviews the advances of researching relation between DNA methylation aberrance and transcription and tumorigenesis in the last decades, especially a recent breakthrough in cancer.
结论FHIT基因的异常转录可能与胃癌的发生有关。
Conclusion the aberrant transcripts of FHIT gene maybe related with the development of gastric cancer.
利用基因芯片对其RNA进行分析，发现大量的基因转录发生改变，包括许多其他部位肿瘤中调节异常的情况也有发现。
RNA was analyzed using oligonucleotide microarrays, and a wide range of transcripts with altered expression identified, including many dysregulated in carcinomas arising at other sites.
基因组学的到来使高通量筛选肿瘤特异性转录和突变成为可能，随即能够识别异常的共用及单一肿瘤相关抗原。
The advent of genomics allows a high-throughput screening for tumor-specific transcripts and mutations, with that identifying novel Shared and unique TAA.
在转录水平，发现了新的异常剪接基因。
On transcriptional level, no foregone alternative splicing event was found.
在转录水平，发现了新的异常剪接基因。
On transcriptional level, no foregone alternative splicing event was found.
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