目的了解拉米夫定耐药与HBV基因型及HBV基本核心启动子(BCP)突变之间的关系。
Objective To investigate the relationship of HBV Lumivudine resistant and HBV genotypes and basic core promoter (BCP) mutation.
与野生基因型携带者相比较，突变杂合和突变纯合基因型携带者的子代罹患CHD的OR值为0.46 (95%CI： 0.31 ~ 0.69)。
Compared with wild type genotype, offsprings of mutant heterozygote and homozygote were at higher risk of CHD, with OR0.46 (95%ci: 0.31 ~ 0.69).
紧密连接蛋白克劳丁-1单克隆抗体能够有效地抑制大多数基因型丙型肝炎病毒感染和自患者分离的高度突变的丙型肝炎病毒准种感染。
The monoclonal antibodies against CLDN1 efficiently inhibited infection by HCV of all major genotypes as well as highly variable HCV quasispecies isolated from individual patients.
结论：由npm 1,FLT3,CEBPA，和MLL基因的突变状态所界定的基因型与细胞遗传学正常的急性髓细胞白血病患者的临床治疗结局之间存在相关性。
Conclusions Genotypes defined by the mutational status of NPM1, FLT3, CEBPA, and MLL are associated with the outcome of treatment for patients with cytogenetically normal AML.
他们估计这三种基因五个突变相关的基因型可以解释这个研究群体中大学一半的AMD患者的同胞危险性。
They estimate that genotypes related to five variants in these three genes explain about half the sibling risk of AMD in the study population.
Couch和他的同事们对几千例BRCA1突变携带群体进行了基因分型，比较了那些被诊断为乳腺癌和非乳腺癌群体的基因型。
Couch and his colleagues genotyped thousands of individuals carrying BRCA1 mutations, comparing genetic patterns in those who had been diagnosed with breast cancer with those who had not.
结论ACI患者血浆型PAF - AH基因9号外显子突变基因型及突变等位基因显著增高。
ConclusionThe prevalence of the mutation genotype and the mutation allele of PAFAH exon 9 in patients with ACI is significantly increased.
目的研究中国人家族性肥厚型心肌病(HCM)的致病基因突变位点，分析基因型与临床表型的相互关系。
Objective to study the disease-causing gene mutations in Chinese hypertrophic cardiomyopathy (HCM) and to reveal the relationship between the genotype and the phenotype.
为了排除基因组dna中假基因的干扰，利用扩增阻滞突变系统，成功地分析了一个肾上腺脑白质营养不良(R 6 17g突变)家系成员的基因型。
To avoid the interference, genomic DNA from the family members with an adrenoleukodystrophy gene mutation (R617G mutation) was analyzed by amplification refractory mutation system.
为了排除基因组dna中假基因的干扰，利用扩增阻滞突变系统，成功地分析了一个肾上腺脑白质营养不良(R 6 17g突变)家系成员的基因型。
To avoid the interference, genomic DNA from the family members with an adrenoleukodystrophy gene mutation (R617G mutation) was analyzed by amplification refractory mutation system.
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