目的：完善和规范基因剔除小鼠技术体系的关键技术环节，建立一套高效的嵌合体制备体系。
Objective: To establish a highly efficient production system of chimeras by perfecting and normalizing the key steps of technology system of gene knockout mice.
基因剔除小鼠的技术体系是生命科学研究，尤其是人类基因组计划和医学实验动物模型等领域所急需的关健技术。
The technology system of gene knockout mice is a most urgently needed technique in the life science research, especially in human genomic project and medical animal models research.
组织学评价提示，移植剔除CCR5基因受者细胞的小鼠肾脏出现了病理损伤并且肝脏存在有更为严重的病理变化。
Histological assessment of the mice indicated pathological lesions in the kidneys and a greater degree of liver pathological changes in mice that received CCR5 KO donor grafts.
组织学评价提示，移植剔除CCR5基因受者细胞的小鼠肾脏出现了病理损伤并且肝脏存在有更为严重的病理变化。
Histological assessment of the mice indicated pathological lesions in the kidneys and a greater degree of liver pathological changes in mice that received CCR5 KO donor grafts.
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