结论黑色素瘤的发生可能与基因组不稳定性有关。
Conclusion The occurrence of melanoma might be associated with genetic genomic instability.
环境与基因型互作的差异性导致了花粉败育的年度不稳定性。
The difference in the interaction between environment and genotype reflected on the unstability of pollen abortion in different years.
依托泊苷能稳定酶催化性循环中的一种共价的拓扑异构酶ii裂解的DNA中间复合物，导致基因组不稳定性和细胞死亡(2,3)。
Etoposide stabilizes a covalent topoisomerase II-cleaved DNA intermediate complex in the catalytic cycle of the enzyme, leading to genomic instability and cell death (2, 3).
而AT M基因遗传不稳定性可能参与慢粒急淋变过程。
The genetic instability of ATM gene may play an important role in the evolution of CML to ALL.
这种肿瘤显示为微卫星不稳定性，一种获得性基因特征暗示DNA修复机制缺陷。
Such tumors display microsatellite instability, an acquired genetic characteristic that indicates defects in DNA-repair machinery.
研究目的遗传的不稳定性是肿瘤生成的最重要的因素之一，而染色体的精确分离是基因物质稳定遗传关键。
Objective genetic instability is one of the most important factors to underlie neoplasia, and precise segregation of the chromosome is critical for stable inheritance of genetic material.
有很多原因可以解释，包括：乏氧驱使基因组不稳定性及改变DNA损伤修复通路的能力。
There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
Defects in DNA damage response can cause genome instability, which induces many human cancers.
DNA损伤反应机制的任何功能缺陷将会引起基因组的不稳定性，从而导致癌症的发生。
Defects in DNA damage response can cause genome instability, which induces many human cancers.
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