方法设计合成1 ~4型登革病毒基因芯片探针，制备成登革病毒基因芯片。
Methods Probes for dengue virus type 1-4 were designed and synthesized, and DNA microarray of dengue virus was prepared.
目的通过观察2型登革病毒（DEN2）NGC株初次感染和再次感染BALB/c小鼠后小鼠血浆中TH1和TH2类细胞因子的产生及其动态变化，研究DEN2感染的免疫机制。
Objective:To observe the dynamic levels of TH1/TH2 cytokines from the plasma of BALB/c mice infected with DEN2 NGC strain and research immune response mechanism.
NS3具有良好的免疫原性，存在多个登革病毒特异性CD4+、CD8+T细胞表位，且多具有型间交叉免疫特性。
The NS3 protein with good immunogenicity appears to be a dominant target for dengue virus-specific CD4+ and CD8+ T cells, and most dengue virus NS3-specific T cells are serotype cross-reactive.
基因序列分析提示：1998年广东省南海市分离的登革病毒2型可能来源于泰国。
The result of DNA sequence analysis suggests that the Guangdong DEN 2 local strains isolated in 1998 were similar to those from Thailand.
结论所建立的方法可用作登革病毒感染的早期诊断及分型。
Conclusion The method of PCR-ELISA we established for early detection and typing of all 4dengue viruses seretypes.
结论所建立的方法可用作登革病毒感染的早期诊断及分型。
Conclusion The method of PCR-ELISA we established for early detection and typing of all 4dengue viruses seretypes.
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