由于具有潜在的毒性如引发胎儿畸形，因此女性在怀孕、哺乳期间禁止使用，在服用维甲酸、异维甲酸期间也不可以怀孕。
Due to potential birth defects, a woman must not take this medication while pregnant or breast feeding and must not become pregnant while taking isotretinoin.
根据我医生的建议时，我迟疑地试图维甲酸在高剂量和强有力的，但什么也没有发生。
Based on my doctor's recommendation, I hesitantly tried Accutane in high and strong dosages, but nothing happened.
分化诱导剂被广泛应用于肿瘤的研究，在肿瘤的预防和治疗方面取得一定的进展，其中以维甲酸类药物效果肯定。
Agents that induce cell differentiation have been widely used in tumor research and achieved progress in the prevention and treatment of tumor. among them, retinoid drug shows confirmative effect.
维甲酸类药物目前在银屑病治疗中广泛应用，疗效较为满意但机制未明。
Retinoids has been used widely in the therapy of psoriasis, which achieved satisfactory effect with unclear mechanism.
在52周的开放性安全试验中，Wortzman博士及其同事报告，655名患者(平均年龄20岁)使用克林霉素-维甲酸凝胶显示安全有效且耐受良好。
In the safety study, a 52-week open-label trial, Dr. Wortzman and colleagues reported clindamycin-tretinoin gel to be safe and well tolerated in 655 patients (mean age, 20 years).
结果在全反式维甲酸诱导前后的细胞之间存在明显的基因表达差异。
Results There were obvious differences in gene expression between human lung cancer cells before and after ATRA treatment.
目的：探讨维甲酸在预防和治疗肿瘤中的作用机制，分离受维甲酸调控的靶基因。
Objective: To explore the mechanism of prevention and therapy by retinoic acid in cancer and isolate ATRA-target gene and explore the mechanism of expression regulation of mitochondrial gene.
这个项目并没有收到很好的成效-从2006年五月到今年6月份，102，606个至少接受过一次异维甲酸治疗的病人其中有178个妇女在怀孕初期使用。DowJones报道。
The program hasn't worked perfectly — 178 women out of 102,606 who received at least one isotretinoin prescription became pregnant from March 1, 2006, through June of this year, Dow Jones reports.
这个项目并没有收到很好的成效-从2006年五月到今年6月份，102，606个至少接受过一次异维甲酸治疗的病人其中有178个妇女在怀孕初期使用。DowJones报道。
The program hasn't worked perfectly — 178 women out of 102,606 who received at least one isotretinoin prescription became pregnant from March 1, 2006, through June of this year, Dow Jones reports.
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