作者认同国际上普遍接受的观点：较其它类型的研究设计，随机对照试验对推断干预措施与效应的因果关联，其真实性最强。
The author identified with views that as compared with the research design of other types, RCTs is the most authentic one in the aspect of causality of efficacy and intervention.
目的阐述在观察性流行病学研究中如何运用孟德尔随机化方法进行科学合理的病因推断，以控制混杂因素和反向因果关联对结果的影响。
Objective to explain how to use Mendelian randomization for reasonable etiological inferences to avoid confounding and reverse causation often seen in observational epidemiological studies.
目的阐述在观察性流行病学研究中如何运用孟德尔随机化方法进行科学合理的病因推断，以控制混杂因素和反向因果关联对结果的影响。
Objective to explain how to use Mendelian randomization for reasonable etiological inferences to avoid confounding and reverse causation often seen in observational epidemiological studies.
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