结论:异种血管内皮生长因子基因重组T7噬菌体疫苗可打破机体对自身vegf的免疫耐受,诱导产生较高水平的特异性抗vegf抗体。
Conclusion: Recombinant T7 phage vaccine expressing xenogenic VEGF can break immunologic tolerance against self-VEGF and induce the producing of specific anti-VEGF antibody.
利用展示有LKVIRK表位的杂合噬菌体作为抗原,免疫C57BL/6J小鼠,然后在小鼠的系统性念珠菌感染模型中评价其免疫保护作用。
The efficacy of hybrid phage particles displaying LKVIRK in inducing immune protection response were studies in C57BL/6J murine model of systemic C.
在经SEA免疫兔血清吸附前,新模型兔血清来源的阳性噬菌体多克隆与SEA免疫兔血清呈阳性反应;
The pool positive phage clones after immune adsorption strongly recognized by the rabbit serum of the new model and the normal model, weakly recognized by the SEA immune rabbit serum.
免疫组化结果显示,表达该序列的噬菌体能与童虫表膜有效结合;
The immunohistochemical stainings showed this sequence specifically binding to the tegument.
免疫组化结果显示,表达该序列的噬菌体能与童虫表膜有效结合;
The immunohistochemical stainings showed this sequence specifically binding to the tegument.
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