本文对检测阿德福韦双匹酯甲醇、乙腈和醋酸异丙酯残留量的方法学进行了研究。
This paper reports the text on the validation of determining procedures of these residual solvents in adefovir dipivoxil.
目的：建立一种快速、简单的测定大鼠血浆中阿德福韦酯水解产物阿德福韦单特戊酸甲基酯和阿德福韦的离子对反相高效液相色谱方法。
Objective:To establish a rapid and simple HPLC method for the determination of adefovir dipivoxil and its metabolites in the rat plasma in vitro.
的确有一些棘手的患者，即使联用拉米夫定和阿德·福韦酯治疗，仍然未出现充分的临床应答，或者在治疗过程中出现了肾毒性。
We do have a number of problem patients who have been on combination lamivudine and adefovir and have not had a sufficient clinical response to combined therapy or who develop nephrotoxicity.
《国际肝病》：然而在中国，恩替卡韦价格昂贵，替诺福韦尚未上市；因此，我们只能使用拉米夫定和阿德·福韦酯。
Hepatology Digest: Unfortunately in China, entecavir is very expensive and tenofovir is not yet licensed so we still use a lot of lamivudine and adefovir.
《国际肝病》：然而在中国，恩替卡韦价格昂贵，替诺福韦尚未上市；因此，我们只能使用拉米夫定和阿德·福韦酯。
Hepatology Digest: Unfortunately in China, entecavir is very expensive and tenofovir is not yet licensed so we still use a lot of lamivudine and adefovir.
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