近年来的研究发现,器官特异性表达的趋化因子及癌细胞表达的受体介导的趋化运动在肿瘤的侵袭和转移过程中发挥着重要的作用。
Recent data indicated that chemotaxis, which involves the chemokines expressed at specific organs and their receptors expressed on tumor cells, plays a crucial role in tumor invasion and spreading.
结果:研究表明许多肿瘤细胞表达趋化因子CXCL12和受体CXCR4,与肿瘤细胞的迁移与转移有密切关系。
Results: Researchs indicated that various tumor cells expressed chemotactic factor CXCL12 and its receptor CXCR4, which was closely related to migration and metastasis of tumor cells.
粘附分子和粘附受体在这一过程中起重要作用,多种细胞因子和趋化因子参与了单核细胞募集的调节。
This is called "monocyte recruitment". Adhesive molecules and adhesive receptors take part and play an important role in the process.
其在多种肿瘤细胞和肿瘤间质细胞膜上有功能性表达,趋化因子受体与肿瘤多种生物学行为密切相关。
These functional recepters can be expressed in kinds of tumor cells and stromal cells and are closely correlated with the biological behavior of tumors.
其在多种肿瘤细胞和肿瘤间质细胞膜上有功能性表达,趋化因子受体与肿瘤多种生物学行为密切相关。
These functional recepters can be expressed in kinds of tumor cells and stromal cells and are closely correlated with the biological behavior of tumors.
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