目的建立甲基化特异性PCR（MSP）技术检测黏着斑激酶相关性鸟苷三磷酸酶调节因子（GRAF）基因启动子甲基化。
Objective To establish the methylation-specific PCR(MSP) to detect methylation of GTPase regulator associated with the focal adhesion kinase(GRAF) gene promoter.
结论肝细胞癌中CHFR基因、EDNRB基因启动子的高甲基化是普遍现象，而3 -OST - 2基因启动子甲基化率较低。
Conclusion promoter methylation of CHFR and EDNRB genes is a common event in HCC, while frequency of promoter methylation of 3-ost-2 is rather low.
正常对照骨髓HPP-CFCP16基因启动子甲基化阳性率较高，而银屑病患者骨髓HPP-CFC P16基因启动子甲基化阳性率低于正常人。
The positive frequency of methylation of P16 gene promoter in HPP-CFC of normal contrasts was higher than that of psoriatic patients.
目的：检测BLU与ARF基因启动子在鼻NK/T细胞淋巴瘤中的甲基化状态，探讨其在肿瘤发生中的作用与分子病理诊断中的应用价值。
AIM: To investigate the hypermethylation of the BLU and ARF promoter in nasal NK/T cell lymphoma from nasopharyngeal mucosa and its roles in tumor genesis and molecular pathological diagnosis.
结论人乳腺癌er基因的失活与其基因启动子高甲基化关系密切。
Conclusion the inactivation of er gene has a close relationship with the abnormal methylation of er gene promoter.
目的：建立检测肝癌胰岛素样生长因子ii (IGF - II)基因启动子p3甲基化状态的方法。
Aim: to detect the methylation at the promoter P3 of human insulin-like growth factor II (IGF-II) gene in hepatocellular carcinoma.
本发明还公开了新的受到DNA甲基化调控的启动子核心序列。
The invention also discloses a new promoter core sequence regulated by DNA methylation.
基因沉默的这种状态与D1基因启动子中的组蛋白甲基化和DNA甲基化修饰受抑制有关，而不涉及DNA序列的改变。
The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations.
目的：研究分泌型卷曲相关蛋白2（SFRP2）基因启动子超甲基化与大肠癌的关系。
Objective:To investigate the function of promoter hypermethylation of secreted frizzled-related protein 2(SFRP2) gene in colorectal cancer.
结论EBV相关胃癌和EBV阳性鼻咽癌组织中病毒潜伏期基因启动子的甲基化状态不同，甲基化是调控EBV潜伏期基因启动子活动的重要机制之一。
Conclusion The methylation status of EBV latent gene promoters in EBVaGC and NPC is different, methylation is one of important mechanisms in regularing the activity of EBV latent gene promoters.
目前研究表明ARF基因在肿瘤发生过程中可有起一定的作用，ARF基因功能的失活可能主要通过该基因启动子高度甲基化。
Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene.
目前研究表明ARF基因在肿瘤发生过程中可有起一定的作用，ARF基因功能的失活可能主要通过该基因启动子高度甲基化。
Recent studies showed that ARF gene may play a role in tumorigenesis; the ARF gene promoter hypermethylation may be the principal mechanism in the inactivation of this gene.
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