美索四氨或哌拉唑嗪以剂量依赖方式抑制吗啡依赖大鼠纳洛酮激发的戒断症状。
In addition, the withdrawal symptoms precipitated by naloxone in morphine dependent rats were blocked by methoctramine(ip) or pirenzepine (it) at single dose injection in a dose dependent manner.
目的：观察不同时程吗啡依赖大鼠心理依赖相关脑区超微结构和突触数量的变化。
Objective: to observe the ultrastructure and synaptic number of cerebral regions related to psychological dependence in rats with different morphine dependent time.
方法：通过单细胞细胞外记录吗啡依赖大鼠腹侧苍白球的电信号，观察吗啡对放电的影响。
Methods:The firing of ventral pallidal neurons in the action of morphine and naloxone was recorded and analyzed in the morphine dependent rats with extracellular single-unit recording.
结论：吗啡显著兴奋吗啡依赖大鼠腹侧苍白球神经元，腹侧苍白球在药物强化过程中起着重要作用。
Conclusi on: the firing of ventral pallidal neurons is excited prominently from morphine in the morphine dependent rats. Ventral pallidum has an important role in drug reward.
目的谷氨酸NMDA受体拮抗剂地卓西平（MK801）对大鼠急性吗啡依赖戒断性情绪反应的影响。
ObjectiveTo investigate the effect of NMDA receptor antagonist MK801 on the negative affection induced by withdrawal from acute morphine dependence in rats.
结论：脊髓和脊髓上中枢神经元pi - 3 K信号通路均参与吗啡依赖的形成及戒断反应的表达。
Conclusion: Both spinal and supraspinal neuronal Phosphoinositide 3-kinase (PI3K) pathway played important role in morphine dependent and naloxone-precipitated withdrawal response in mice.
目的研究急性或慢性吗啡依赖和戒断大鼠脑组织环腺苷酸反应元件结合蛋白-1 （CREB-1）表达的变化。
Objective To investigate the changes in CREB-1 protein expression in three brain regions induced by acute or chronic morphine dependence and withdrawal.
视知觉学习训练似乎可以促进认知功能康复的进程，其机理可能是视知觉学习训练重新调整了吗啡依赖的神经可塑性。
Perceptual training could speed up recovering the cognition, we assume the mechanism is that perceptual training can adjust the neuroplasticity of dependence on morphine again.
结论：吗啡影响神经细胞嘌呤核苷酸代谢，使细胞内腺苷酸及腺苷水平增高，这可能是吗啡依赖和耐受形成的机理之一。
Conclusion morphine may affect purine nucleotide metabolism of nerve cells, increase the adenylate and adenosine levels, which may be one of the mechanism of morphine dependence and tolerance.
在饮水中溶入硫酸吗啡，逐日提高吗啡浓度，SD大鼠在饮入吗啡后第10天产生明显的吗啡依赖。而同样方法饮入盐酸吗啡效果较差。
Morphine physical dependence was induced on day 10 in SD rats by daily administration of morphine sulphate(MS), but not morphine hydrochloride(MH), in their drinking water.
方法将SD大鼠分为6组：吗啡依赖10天组，吗啡依赖10天对照组，吗啡依赖30天组，吗啡依赖30天对照组，脱毒组，脱毒对照组。
Methods SD rats were divided into 6 groups: 10-days morphine dependent group and its control, 30-days morphine dependent group and its control, detoxification group and its control.
高压的生活再加上对吗啡等止痛药物的依赖，导致她患上了出血性胃溃疡和肝损害。
High living, including a dependence on painkillers like morphine, helped bring her a bleeding ulcer and liver damage; more than once she collapsed dramatically onstage.
目的：用胞外记录的方法分别观察伏隔核和海马腹侧下托对吗啡的反应性，探讨其在药物心理依赖形成过程中所处的地位。
Objective:Using the outer-cell recording to observe the morphine responses of nucleus accumbens and ventral subiculum, and explore the function of them in the process of drug-dependence.
伏隔核中的GABA含量显著下降，GLU/GABA值显著升高，表明吗啡精神依赖时伏隔核处于去抑制状态。
The nucleus accumbens were in disinhibited condition in morphine CPP rats for the content of GABA decreased significantly and the ratio of GLU/GABA increased significantly.
一氧化氮（NO）是与N甲基D 天（门）冬氨酸（NM DA）受体活性相关的一种细胞内信使分子，在吗啡耐受和依赖中起作用。
Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.
当受试者服用阿朴吗啡40分钟后的测试结果为，酒精依赖组的平均反应时间为392分钟，而对照组为417分钟。
When test performance was evaluated 40 minutes after subjects received apomorphine, the mean reaction times were 392 minutes in alcohol-dependent subjects and 417 minutes in controls.
以饮用吗啡药水法建立小鼠依赖模型，探讨其免疫机能的改变。
Mouse dependence model was established by drinking increasing concentrations of morphine( Mor) in tap water, with which several parameters of immune function were evaluated.
莫凯蒂说：“最理想的就是，我们可以利用这些知识研发出一种类似于吗啡的化合物，但不具有吗啡所拥有的典型依赖性和耐受性问题。”
"Ideally, we can use this information to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has, " Mocchetti said.
方法：依据吗啡成瘾动物的依赖性评价指标，选择痛阈和纳络酮跳台反应作为观察项目。
METHODS: According to evaluation index of dependence in Morphine addicted animals, we chose pain threshold and naloxone urged jumping response as items to observe.
方法··：毁损依赖大鼠腹侧苍白球，利用条件性位置偏爱实验测定术前、术后依赖大鼠对注射吗啡侧的偏爱程度，评价腹侧苍白球在药物强化效应程度中的作用。
Method: Electrical lesions of ventral pallidum were done in 12 morphine dependent rats and the drug seeking behavior was measured by conditioned place preference paradigm.
方法··：毁损依赖大鼠腹侧苍白球，利用条件性位置偏爱实验测定术前、术后依赖大鼠对注射吗啡侧的偏爱程度，评价腹侧苍白球在药物强化效应程度中的作用。
Method: Electrical lesions of ventral pallidum were done in 12 morphine dependent rats and the drug seeking behavior was measured by conditioned place preference paradigm.
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