• 肉牙形成吗啡剂量浓度相关时间梯度作用一项联合磁共振和组织病理学的研究

    Time Course and Role of Morphine Dose and Concentration in Intrathecal Granuloma Formation in Dogs: A Combined Magnetic Resonance Imaging and Histopathology Investigation.

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  • 但是最终的遭遇非常可怕,她的腹部放射治疗灼伤非常严重肿瘤增殖给她带来疼痛远远超过吗啡的镇定作用

    But by the end her sufferings were horrible, her abdomen badly burnt by the radiation treatment, the pain from her multiplying tumours far beyond the reach of morphine.

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  • 吗啡通过作用神经突触来缓解疼痛同时也兴奋了胶质细胞可能也加剧该药作用嗜睡耐受,疼痛加剧和成瘾

    Morphine deadens pain by acting at nerve synapses, but it also activates glial cells, possibly worsening the drug's side effects, such as drowsiness, tolerance, worsening of pain, and addiction.

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  • 结论针刺通过抑制NOS活力NO生成改善吗啡戒断症状过程中起到良性调节作用

    Conclusion: Acupunctureplay good regulation role in the course of improving morphine abstinence syndrome by inhibiting NOS activity and decreasing NO production.

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  • 诱发反应具有反应阈值潜伏期反应形式复杂、后作用时间长、可静脉注射吗啡抑制等特点。

    The evoked responses have the specificities with higher threshold, longer latency, complex reactive patterns, and being inhibited by the action of morphine.

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  • 使用吗啡一周随着病人耐受止痛效果随之降低同时病人遭受成瘾便秘作用

    After a week of morphine use, its effectiveness decreases as patients build tolerance, and patients also experience negative side effects like addiction and constipation.

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  • 结论咪唑安定联用吗啡小儿创伤机械通气中的镇静镇痛作用显著值得推广

    Conclusion Midazolam combined with morphine during ventilation treatment in pediatric trauma cases has obvious sedative effect and is worth spreading in clinical practice.

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  • 结论吗啡慢性注射可以导致学习记忆损害,而电针对大鼠吗啡慢性注射所造成学习记忆损害有一定的改善作用

    Conclusion Chronic injection morphine could induce defects of the learning and memory in the rat. Meantime, ea could improve morphine-induced lesion of learning-memory.

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  • 一氧化氮(NO)是与N甲基D 天(门)冬氨酸NM DA受体活性相关一种细胞内信使分子吗啡耐受依赖作用

    Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.

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  • 结论:吗啡显著兴奋吗啡依赖大鼠腹苍白球神经元苍白球药物强化过程中起着重要作用

    Conclusi on: the firing of ventral pallidal neurons is excited prominently from morphine in the morphine dependent rats. Ventral pallidum has an important role in drug reward.

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  • 目的探讨阿扑吗啡是否对6-羟基多巴胺毁损纹状体帕金森病模型神经保护作用

    Objective To investigate the possible neuroprotective effect of dopamine(DA) receptor agonist R-apomorphine(R-APO) on the 6-hydroxydopamine(6-OHDA)-induced rat model of Parkinson's disease.

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  • 我们发现随着异源二聚体的具体,大脑选择性吗啡治疗慢性疼痛起作用阻碍单个受体吗啡止痛作用传导

    "We found that the brain selectively responds to chronic morphine by increasing heteromer abundance, blocking individual receptors from signaling the analgesic response to morphine, " said Dr. Devi.

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  • 方法··:毁损依赖大鼠腹苍白球利用条件性位置偏爱实验测定术前、术后依赖大对注射吗啡侧的偏爱程度,评价腹侧苍白球在药物强化效应程度中的作用

    Method: Electrical lesions of ventral pallidum were done in 12 morphine dependent rats and the drug seeking behavior was measured by conditioned place preference paradigm.

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  • 结论抑制慢性吗啡注射所引起脊髓jnk激活可能胍丁胺抗吗啡镇痛耐受作用机制之一。

    Conclusion Inhibition of chronic morphine-induced spinal JNK activation may be one of the mechanisms underlying the blockage of morphine antinociceptive tolerance by agmatine.

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  • 结论痛稳素及其碳末端八肽脊髓以上水平逆转孤啡肽对抗吗啡肽1及内吗啡肽2的镇痛作用

    CONCLUSION Nocistatin and nocistatin (10~17) were shown to reverse the effects of nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia at supraspinal level.

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  • 结论痛稳素及其碳末端八肽脊髓以上水平逆转孤啡肽对抗吗啡肽1及内吗啡肽2的镇痛作用

    CONCLUSION Nocistatin and nocistatin (10~17) were shown to reverse the effects of nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia at supraspinal level.

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