药物的溶解性,在胃肠道中的稳定性,膜的通透性和全身代谢是影响口服药物吸收的主要因素。
The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
口服补液盐溶液在小肠内吸收,从而补充水和电解质的丢失。
The ORS solution is absorbed in the small intestine, thus replacing the water and electrolytes lost.
口服补液盐在小肠吸收,可补充随粪便流失的水和电解质。
ORS is absorbed in the small intestine and replaces the water and electrolytes lost in the faeces.
口语中生物有效性的意思是:口服的某种药或者某种物质可以被身体吸收和利用。
Orally bioavailable means that a drug or other substance that is taken by mouth can be absorbed and used by the body.
虽然口服HA后的效果已得到认可,但是HA口服后能否被吸收,如能吸收则机制如何,目前还不明确。
The effect of ha after oral administration has got the approbation, but whether or not ha can be absorbed, if it can, and how mechanism is, is still unclear now.
口服是最常用的给药途径,其吸收涉及药物通过胃肠道上皮细胞膜的转运。
For oral administration, the most common route, absorption refers to the transport of drugs across membranes of the epithelial cells in the GI tract.
氯化N-三甲基壳聚糖是壳聚糖的部分季铵化衍生物,能溶于中性及碱性环境中,可作为肽类药物的口服吸收促进剂。
Ntrimethyl chitosan chloride, a partially quaternised derivative of chitosan, which is soluble in neutral and basic environment, can be used as an absorption enhancer of oral peptide drugs.
背景:法莫替丁作为组胺H_2受体拮抗剂,其口服吸收不完全,生物利用度约为37% - 50%。
Background: As one of the histamine H_2 receptor antagonist, the oral absorption of famotidine is not complete, its bioavailability is about 37%-50%.
口服后,头孢氨苄是通过肠道吸收障碍。
After oral administration, Cephalexin is absorbed through the intestinal barrier.
方法以国内外发表的文献为依据,总结归纳了壳聚糖及其衍生物促进药物口服吸收中的机理及影响因素。
METHODS Sum up the studies of the mechanism and influence factors of Chitosan and its Derivatives in oral drug absorption.
结果药物的溶解性、稳定性、膜通透性和首过作用等生物药剂学性质是影响药物口服后经胃肠道吸收的主要因素。
Results The solubility, stability in gastrointestinal tract, membrane permeability and presystemic metabolism of drugs were the major factors on oral drug absorption.
目的综述药物的生物药剂学性质对药物口服吸收的影响。
Objective To review the impacts of biopharmaceutical characteristics on oral drug absorption.
前药研究是提高生物药剂学分类系统中第III和IV类药物口服吸收的有效途径之一。
Prodrug is an effective way to improve the oral absorption of the drugs which belong to Biopharmaceuticals Classification System(BCS) class III and IV.
口服摄入后,它在小肠吸收。
After oral ingestion, it is absorbed in the small intestine.
但灯盏花素口服剂型吸收较差,绝对生物利用度低,而注射给药给长期治疗的病人带来许多不便和痛苦。
But the oral dosage forms of Breviscapine are poorly absorbed in body, and they have low absolute bioavailability.
目的:对中药冰糖增加口服四环素吸收作用机理进行初步的实验研究。
Aims: To study the mechanism by which crystal sugar enhances absorption of tetracycline in the rat intestine.
由于其口服难吸收、生物利用度低的原因,临床只用于静脉给药。这不仅给患者带来用药的不便,而且也限制了葛根素的临床应用。
However, for the sake of its low oral absorption and bioavailability, now in clinic Puerarin is administrated only by vein injection, which is inconvenient for patients and limits its clinical use.
如果没有发现口服吸收的药物,格林森医生将因此而受到牵连。
If no orally consumed drugs were found then Dr. Greenson would have been implicated.
目的探讨透明质酸口服吸收的机制。
OBJECTIVE To study the absorption of hyaluronic acid (HA) administrated orally in rats.
利用非微粒脂质给药系统,药物不必经过溶出的步骤,从而可以显著的提高疏水性药物的口服吸收。
Oral absorption of hydrophobic drugs can be significantly improved using lipid-based non-particulate drug delivery systems, which avoid the dissolution step.
低生物利用度最常见于水溶性差、吸收慢的药物的口服剂型。
Low bioavailability is most common with oral dosage forms of poorly water-soluble, slowly absorbed drugs.
混合后的配方不需要注射,可以通过口服方法服用,使得吸收更慢,同时也就降低了毒性。
The new formula does not need to be injected. It can be taken orally which allows slower absorption with less toxicity.
过度使用可能会通过减少肠道对营养物质和适当的过境速度增加口服药物的吸收。
Overuse may decrease absorption of nutrients and oral medications due to increased speed of transit through the intestines.
本品口服吸收完全,几乎达到100%。
This product is completely absorbed orally, reaching almost 100%.
吸收过程是决定口服药物生物利用度的重要因素,然而很多药物的吸收机制还不明确。
The absorption process is an important factor in determining the bioavailability of orally administered drugs. however, the absorption mechanism of many drugs is not clear.
这提示1,25二羟基维生素d 3口服制剂的浓缩剂型,将有利于其吸收利用。
It is indicates that the concentrated capsule of 1, 25-dihydroxyvitamin D3 oral preparation would be in favor of absorption and utilization.
讨论了影响自胃肠道吸收药物生物利用度的因素,对提高难溶性药物口服生物利用度的方法进行了综述。
Factors that affect the oral bioavailability of water insoluble drugs were discussed, and a review was given on the measures of improving the oral bioavailability of water insoluble drugs.
目的:在细胞水平研究胰岛素脂质体的口服吸收机制。
OBJECTIVE To study the delivery mechanism of trans-intestinal epithelium transportation of insulin liposome.
灯盏乙素经PEG化后水溶性提高,并获得了适于口服吸收的理想的分配系数。
By PEG modification, the greatly increased water solubility and desirable partition coefficient of scutellarin were obtained.
灯盏乙素经PEG化后水溶性提高,并获得了适于口服吸收的理想的分配系数。
By PEG modification, the greatly increased water solubility and desirable partition coefficient of scutellarin were obtained.
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