例如,艾比特思和名为表皮生长因子受体(EGFR)的细胞表面蛋白的结合。
Erbitux, for example, binds to a cell-surface protein called epidermal growth-factor receptor (EGFR).
许多种类的肿瘤可产生比普通细胞高得多的表皮生长因子受体,影响之一就是刺激了肿瘤细胞的扩散。
Many types of tumour produce far more EGFR than normal cells do, and one effect of that is to stimulate the proliferation of tumour cells.
“从不吸烟的患者对一类叫表皮生长因子受体抑制剂的药物反应更好,因为这类患者有表皮生长因子受体基因突变的可能性更大一些。”鲁丁说。
"Patients who never smoked respond better to a certain class of drugs called EGFR inhibitors, because lung cancer in these patients more often contain mutations in the EGFR gene," Rudin says.
表皮生长因子受体通常促进细胞的生长发育,一旦发生基因变异,会使细胞不受控制地生长。细胞不受控制地生长,这正是癌症的特征。
EGFR normally promotes cell growth and development, and when mutated, allows the uncontrolled growth of cells that is the hallmark of cancer.
人类肿瘤细胞表达高水平的生长因子及其受体。
Human tumor cells expressed high levels of growth factor and its receptor.
肺癌中表皮生长因子受体的突变及对靶向治疗的敏感性。
Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer.
中国的非小细胞肺癌病人中吉非替尼敏感的表皮生长因子受体酪氨酸激酶区域的突变。
Gefitinib-sensitive mutations of the epidermal growth factor receptor tyrosine kinase domain in chinese patients with non-small cell lung cancer.
共有210名患有人表皮生长因子受体2 (HER2)阳性的早期乳腺癌的女性患者参加了实验。
A total of 210 women with early breast cancer who tested positive for human epidermal growth factor receptor 2 (HER2) were enrolled.
他们在细胞发现了一种分子,称为“生长因子受体”,即帮助肿瘤在大脑中的增值。
They found a molecule in the cells, called a "growth factor receptor", that AIDS the tumor's expansion in the brain.
血管内皮细胞生长因子(VEGF)及其受体在肿瘤血管新生中起重要作用,阻断VEGF的生成已成为抗肿瘤治疗的新靶点。
Vascular endothelial growth factor (VEGF) and its receptor play a critical role in tumor-associated angiogenesis and have become the new targets of anti-tumor therapy.
非小细胞肺癌病人的表皮生长因子受体基因突变的临床病理意义。
Clinicopathologic Significance of the Mutations of the Epidermal Growth Factor Receptor Gene in Patients with Non-Small Cell Lung Cancer.
血管内皮细胞生长因子及其受体在肿瘤新生血管形成中起重要作用,成为肿瘤治疗的新靶点。
Vascular endothelial growth factor (VEGF) and its receptor play a critical role in tumor associated angiogenesis and has become the new targets of anti tumor therapy.
肺癌中表皮生长因子受体基因的临床和生物学特点。
Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers.
十多年前就取得了重大进展,一个加州的生物科技公司Genentech(中文名:基因泰克)发行了一种药物,这种药物攻击蛋白质HER2(中文名:人表皮生长因子受体- 2)含量过多的乳腺癌细胞。
A breakthrough came more than a decade ago when Genentech, a Californian biotech firm, launched a drug that attacks breast-cancer cells with too much of a certain protein, HER2.
目的:在众多血管再生性因子中,血管内皮生长因子及其受体2是公认的促使血管生成的关键性因素。
OBJECTIVE Vascular endothelial growth factor VEGF and its receptor 2 are the generally accepted key factor on the formation of blood vessel in numerous blood vessel regeneration factors.
生长因子与其相幢受体之间,可能存在正反馈调节机制。
There may be positive regulation mechanism between growth factor and its corresponding receptors.
现已知fsh受体的激活可以促进血管内皮生长因子(VEGF)的信号传导通路,而VEGF可以促进包括肿瘤组织在内的血管的生长。
Activation of the FSH receptor is known to contribute to the signaling of vascular endothelial growth factor (VEGF), a protein that stimulates the growth of blood vessels, including those in tumors.
目的:探讨各种生长因子及其受体在正常角膜和角膜缘的表达及分布规律。
Purpose: To investigate the expression and distribution characteristics of growth factors and their receptors in normal cornea and limbus .
表皮生长因子受体(EGFR)在人类肝细胞广泛表达,表皮生长因子可能是肝细胞生长中必须的有丝分裂原。
Epidermal growth factor receptor (EGFR) is frequently expressed in human hepatoma cells, and EGF may be one of the mitogens that are needed for the growth of hepatoma cells.
目的探讨肝细胞生长因子及其受体在胃癌组织中表达的意义。
Objective to investigate the role of expression of hepatocyte growth factor and its receptor in gastric cancer.
目前治疗胶质母细胞瘤的疗法直接采用抑制另一种细胞受体,即上皮生长因子受体(EGFR)。
Current therapies to treat glioblastomas are directed toward blocking the activity of another cellular receptor called epithelial growth factor receptor (EGFR).
目的研究抑制素、表皮生长因子受体在人卵巢颗粒细胞瘤中的表达及临床意义。
Objective To investigate the expression of inhibin, epidermal growth factor receptor in human ovarian granulosa cell tumor and their clinical significance.
目的确定人成纤维细胞生长因子受体1 (FGFR1)的配体精细结合位点。
Objective to determine fine binding site of ligand to fibroblast growth factor receptor 1 (FGFR1).
转录最高的基因与功能相关,如细胞粘附,基质蛋白,生长因子,受体和蛋白酶。
The most highly transcribed genes relate to functional groupings such as cell adhesion, matrix proteins, growth factors and receptors, and proteases.
结论:表皮生长因子受体抑制剂ag1487可对舌鳞癌细胞产生明显的增殖抑制作用。
Conclusion: Epidermal growth factor receptor inhibitor AG1487 may retard cell cycle, and then inhibit the proliferation of tumor cells.
目的:检测表皮生长因子受体(EGF - R)在舌癌患者常见舌苔中的表达水平,探讨EGF - R与舌苔形成的关系。
Objective: to investigate the relationship between the level of epidermal growth factor receptor (EGF-R) and tongue fur formation in tongue cancer patients.
目的:了解表皮生长因子受体抑制剂AG1487对舌鳞癌细胞的抑制增殖作用。
Objective:To investigate the inhibitory effect of epidermal growth factor receptor inhibitor AG1487 on the proliferation of tongue cancer cells.
目的观察血管内皮生长因子受体1 (VEGFR1)阳性造血祖细胞与人大肠癌转移的关系及机制。
Objective to investigate the relation of vascular endothelial growth factor receptor 1 (VEGFR1) -positive hematopoietic progenitor cell with the metastasis of human colorectal carcinoma.
目的探讨表皮生长因子受体与细胞增殖、转化的关系。
Objective to explore the relationship between epidermal growth factor receptor (EGFR) and cell proliferation and transformation.
目的探讨表皮生长因子受体与细胞增殖、转化的关系。
Objective to explore the relationship between epidermal growth factor receptor (EGFR) and cell proliferation and transformation.
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