目的探讨针对人宫颈癌基因(HCCR)反义核苷酸影响肝癌细胞增殖、凋亡的作用。
Objective to investigate the effect of antisense nucleotide of human cervical cancer oncogene (HCCR) on the cell proliferation and apoptosis of HepG2 cells.
小鼠ptp - 1b基因敲除及反义核苷酸治疗实验表明PT P - 1b是治疗糖尿病和肥胖症的潜在靶标。
Recent PTP-1B gene knock-out studies and anti-sense oligonucleotide (ASO) treatment in mice have identified PTP-1B as a potential target for chemotherapy of diabetes and obesity.
目的：探讨反义寡核苷酸对胆囊癌细胞端粒酶活性的影响及对胆囊癌细胞生长增殖的作用。
Objective: To study the antisense oligonucleotide mediated inhibition on telomerase activity and cell proliferation of GBC-SD cell.
结论：EAAC 1反义寡核苷酸对急性脑缺血损伤有神经保护作用。
CONCLUSION: EAAC1 antisense oligonucleotide has the neuroprotective effect against acute cerebral ischemia injury.
方法将SPA-PLL交联物、CD44抗体和反义寡核苷酸以适宜的质量比混合即可组装成抗体靶向寡核苷酸复合物；
Methods The antibody-targeted complex could be prepared by mixing SPA-PLL conjugate, oligodeoxy nucleotide and anti-CD44 antibody based on their optimal mass ratio.
目的评价生存素反义寡核苷酸在荷肝癌小鼠中的治疗作用。
Objective To evaluate the therapeutic effect of antisense oligonucleotide targeting Survivin in the treatment of tumor-bearing nude mice.
目的探讨IGF - IR反义寡核苷酸对食管癌ec9706细胞增殖、分化的影响。
Objective To investigate the effects of antisense oligodeoxynucleotides (ASODNs) of IGF-IR on the proliferation and differentiation of EC9706 cell line.
目的：利用纳米载体增强端粒酶反义寡核苷酸对肝脏肿瘤细胞生长的抑制作用。
Objective: To investigate the growth inhibition of antisense oligonucleotides of telomerase on liver tumor cell enhanced by albumin nanoparticles.
目的探讨IL12反义寡核苷酸对狼疮肾炎(LN)患者单个核细胞(PBMC)分泌免疫球蛋白的影响。
Objective To investigate the effect of IL 12 antisense oligonucleotides on immunoglobulin secretion by PBMC from patients with active lupus nephritis (LN).
目的：研究组织因子（TF）反义寡脱氧核苷酸（AS/TF）对大鼠心肌缺血再灌注损伤的作用。
Objective To study the effects of antisense oligodeoxynucleotide(AS/TF) for rat tissue factor (TF) on the myocardial ischemic reperfusion injury.
目的观察vegf反义寡核苷酸对膀胱癌细胞VEGF表达的抑制情况。
Objective To study inhibition of VEGF expression in human bladder carcinoma cells by antisense oligonucleotides.
目的探讨超声介导脂质体微气泡转染反义寡核苷酸ha- 2741的有效性。
Objective To explore the efficiency of transfection of antisense oligonucleotides HA-2741 by ultrasound mediated liposome microbubbles.
目的探讨辐射促转染的胰岛素样生长因子1受体(IGF 1r)反义寡核苷酸(ason)对肿瘤组织的杀伤效果。
Objective to investigate the killing effect of insulin-like growth factor-1 receptor (IGF-1R) antisense oligodeoxynucleotides (ASON) in combination with ionizing radiation on tumor.
目的：探讨端粒酶逆转录酶(TERT)的反义寡核苷酸(A SODN)对甲状腺癌(TC)细胞凋亡的影响。
AIM: to investigate the effect of antisense oligonucleotides (ASODN) encoding telomerase reverse transcriptase (TERT) mRNA on thyroid carcinoma (TC) cell apoptosis.
目的观察增殖细胞核抗原（PCNA）基因反义脱氧寡核苷酸对人多形性胶质母细胞瘤细胞增殖的影响。
Objective To observe the effect of proliferating cells nuclear antigen (PCNA) antisense oligodeoxynucleotides on the proliferation of human multiform glioblastoma cells.
目的：筛选出高效特异而无毒的抗hbv反义寡核苷酸片段。
Objective: to screen the high performance, specific and nontoxic anti HBV antisense oligonucleotide fragment.
采用DAPI染色技术观察hpk1反义寡核苷酸对OGD诱导的海马神经元凋亡的作用。
DAPI staining was used to investigate the role of HPK1 antisense oligodeoxynucleotides in hippocampus neuron death induced by OGD.
结果VEGF反义寡核苷酸对膀胱癌细胞的VEGF表达有明显的抑制作用。
Results VEGF antisense oligonucleotides obviously inhibited VEGF expression in human bladder carcinoma cells and proliferation of endothelial cells.
结果PCNA反义寡核苷酸可明显抑制BT325细胞的生长；
Results PCNA antisense oligodeoxynucleotides could significantly inhibit the growth of BT325 cells line.
成功的反义显像要求反义寡核苷酸易被细胞摄取、耐核酸酶、杂交稳定、标记简单。
The requirements for ideal antisense imaging include easy intakeing by cells, convenient labelling, stable hybridization and the tolerance against nuclease.
目的研究角质形成细胞生长因子(KGF)及其受体(KGFR)反义寡核苷酸对KGF介导的细胞周期和凋亡变化的抑制作用。
Objective to investigate the effects of keratinocyte growth factor (KGF) and KGF receptor (KGFR) antisense oligonucleotide (ASODN) on cell cycle and apoptosis of HaCat cells.
目的：观察eb病毒BHRF 1反义寡核苷酸片段对鼻咽癌SUNE1细胞株增殖的影响。
Objective: To investigate the effects of EBV BHRF1 antisense oligodeoxynucleotide (aso) on the proliferation of poorly differentiated nasopharyngeal carcinoma (SUNE1) cell lines.
与单独使用反义寡核苷酸相比较，萘二酰亚胺对寡核苷酸的共价修饰显著地提高了反义寡核苷酸对KB-A - 1细胞生长的抑制。
Compared with the unmodified one, the inhibition of antisense oligonucleotides to the growth of KB - a - 1 cell was increased by conjugating with naphthyl imide.
基因治疗是将DNA转染进入目的细胞，修复遗传错误或产生治疗因子。反义寡核苷酸的应用是基因治疗的主要手段之一。
The aim of gene therapy is to transfect DNA into target cells, in which utilizing antisense oligonucleotides is a main method.
目的：观察端粒酶反义寡聚脱氧核苷酸对人胃癌细胞株的作用。
To observe the effect of telomerase antisense oligodexynucleotides on gastric cancer cell line.
MTT法检测加入反义寡核苷酸后对转染的包装细胞生长的影响。
MTT was used to detect the cell growth of the packaging cells.
Thornton说：“目前以学生课本中没有反义寡聚核苷酸的章节，但是在不久的将来这点将改变。”
"The current textbooks for medical students do not have chapters on antisense oligonucleotides, but this will change in the near future," said Thornton.
【摘要】目的探讨增殖细胞核抗原(pcna)反义寡核苷酸对大鼠胶质瘤生长的抑制作用。
Abstract Objective to study the inhibitory effect of PCNA antisense oligonucleotides on the growth of rat glioma.
【摘要】目的探讨增殖细胞核抗原(pcna)反义寡核苷酸对大鼠胶质瘤生长的抑制作用。
Abstract Objective to study the inhibitory effect of PCNA antisense oligonucleotides on the growth of rat glioma.
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