本发明描述了三官能双特异性抗体用于制备用来预防和治疗肿瘤疾病的药物组合物的应用。
The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases.
本发明涉及一种制备异多聚体多肽如双特异性抗体、双特异性免疫粘附素和抗体—免疫粘附素嵌合体的方法。
The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras.
目的：鉴定自制的抗CD3-抗胶质瘤双特异性抗体（双抗）的双向结合能力，测定其免疫活性及其对T淋巴细胞的作用。
Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb) , and to study its effect on T lymphocytes cells.
因此，ELISA间接法敏感性高、特异性强和重复性好，可代替ELISA间接双抗体夹心法以检测RV血清抗体。
Thus, indirect ELISA proved to possess high sensitivity, specificity and reproducibility, it can be used to replace indirect sandwich ELISA for the detection of serum antibody against RV.
结果该双功能抗体与舌癌组织特异性结合率为85.29%，与血管内皮细胞结合率为82.35%。
Results: the specific conjugation rate between bifunctional antibody and lingual cancer tissue was 85.29%, and that between the antibody and vascular endothelial cells was 82.35%.
结论建立的双抗体夹心elisa检测MP抗原具有快速、简便、灵敏度高、特异性强等优点。
Conclusions Antibody-sandwich ELISA for detection of mp antigen is simple, rapid, sensitive and specific.
方法：采用间接ELISA法和双抗原夹心ELISA法检测SARS患者血清中特异性抗体水平。
Methods The specific antibody in the serum of135SARS patients were detected by in direct ELISA and double antigen sandwich method.
还提供免疫缀合物、双特异性分子以及包含本发明抗体和任选地一种或多种其它治疗剂的药物组合物。
Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic.
还提供了包含本发明抗体的免疫偶联物、双特异性分子和药物组合物。
Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided.
采用免疫双扩法鉴定单克隆抗体类型，ELISA法、免疫双扩法鉴定单克隆抗体的特异性。
Double immunodiffusion assay was used to identify the type and subclass of monoclonal antibody. ELISA and double immunodiffusion assay were used to determine the specificity.
采用免疫双扩法鉴定单克隆抗体类型，ELISA法、免疫双扩法鉴定单克隆抗体的特异性。
Double immunodiffusion assay was used to identify the type and subclass of monoclonal antibody. ELISA and double immunodiffusion assay were used to determine the specificity.
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