目的建立正常人和矽肺人群血清双向电泳图谱，寻找矽肺血清差异蛋白，进一步探索其发病机制。
Objective To establish 2-dimensional gel electrophoresis (2-de) images and seek differentially expressed serum proteins for understanding the pathogenesis of silicosis.
通过对双向电泳图谱的初步观察可以看到，蛋白质主要集中在等电点5—8和分子量28kd—66 KD之间。
From 2-d electrophoresis maps, we can find that most of proteins focused between pI5 - pI 8 and molecular weight 28kd-66kd.
结果双向电泳图谱上有6个点在两组间存在明显差异，4个蛋白质点在GBS疾病组中表达明显上调，2个降低。
ResultsThere were 6 protein spots that had significant differences in expression between the two groups. Expressions of 4 protein spots in the GBS group increased and 2 decreased.
肿瘤患者脑脊液和正常对照脑脊液双向电泳图谱有明显差别，但是本实验尚未对这些差异蛋白进行质谱鉴定，所以未找出肿瘤特异蛋白。
There are obvious difference between the two 2D gels, but the different protein spots are not identified by mass spectrum, so the tumor special protein is not found.
肿瘤患者脑脊液和正常对照脑脊液双向电泳图谱有明显差别，但是本实验尚未对这些差异蛋白进行质谱鉴定，所以未找出肿瘤特异蛋白。
There are obvious difference between the two 2D gels, but the different protein spots are not identified by mass spectrum, so the tumor special protein is not found.
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