目的了解TPO模拟肽L203对骨髓抑制后大鼠的促血小板生成作用及对大鼠巨核细胞分化、增殖的影响。
Objeactive To research on TPO analogue peptide L203 to the thrombopoiesis effective and cultural megakaryocyte differentiation, the multiplication influence in myelosuppressive rats.
方法：分析30例MA患者的外周血象变化及骨髓中病态粒细胞、病态巨核细胞和可染铁的变化。
Methods: We selected 30 patients with ma randomly then analyzed the changes of peripheral blood maps and stainable iron in morbid granular cells and macrophages of these patients.
初发时巨核细胞计数增高及出现病态变化者缓解率低，预后不良。
Newly diagnosed patients with higher celluler count of megakaryocytes and dysmegakaryopoiesis had less complete remission rate and poor prognosis.
另6例JAK2V617F点突变阴性患者仅1例有血栓史，血小板数目及骨髓巨核细胞数目相对较低。
Out of other 6 IMF patients without JAK2V617F point mutation only 1 patient had thrombosis, and lower counts of platelets in perepheral blood and megakaryocytes in bone marrow.
另6例JAK2V617F点突变阴性患者仅1例有血栓史，血小板数目及骨髓巨核细胞数目相对较低。
Out of other 6 IMF patients without JAK2V617F point mutation only 1 patient had thrombosis, and lower counts of platelets in perepheral blood and megakaryocytes in bone marrow.
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