利用乙二胺为连接臂合成乳糖化-去甲斑蝥素修饰物。
目的采用尿药法进行去甲斑蝥素人体药动学研究。
OBJECTIVE To study pharmacokinetics of norcantharidin in human by urinary excretion method.
结论去甲斑蝥素壳聚糖具有抗肿瘤活性和升高白细胞作用。
Conclusion Norcantharidin chitosan derivative has antitumor activity and increasing leukocyte effect.
目的采用新型壳聚糖载体研究去甲斑蝥素的双重肝靶向制剂。
OBJECTIVE to investigate a dual hepatocyte-targeting preparation of norcantharidin with model chitosan carrier.
本发明公开了一种去甲斑蝥素二聚体衍生物及其合成方法与应用。
The invention discloses a norcantharidin dimer derivate as well as a synthetic method and application thereof.
结论尿药法估算去甲斑蝥素人体药动学参数取样方便，样本处理简单。
CONCLUSION it's suitable to estimate the pharmacokinetic parameters by urinary excretion method, with the merits of convenient sample collection and simply specimen disposal.
方法利用乙二胺为连接臂合成乳糖化-去甲斑蝥素修饰物，并考察其相关理化性质；
METHODS Lac-NCTD was synthesized with ethanediamine as truss arm, and then its properties were studied.
方法以N-乳糖酰壳聚糖为载体，通过离子诱导法，制备去甲斑蝥素N-乳糖酰壳聚糖纳米粒。
METHODS Norcantharidin-associated galactosylated chitosan nanoparticles were achieved by ionic cross-linkage process with galactosylated chitosan as carrier.
具有较大粒径的去甲斑蝥素壳聚糖纳米粒能够实现肝脏靶向，提高药物疗效，降低全身毒副作用。
Through the adjustment on the two molecular parameters, CS-NP with various mean size and drug release rate could be obtained.
方法：将乳糖化-去甲斑蝥素与磷脂聚合成药物磷脂复合物，并采用FT-IR、DSC和1H-NMR对其进行表征。
Methods: Lac-NCTD phospholipid complex was prepared using solvent-evaporation, and its correlated physicochemical properties were confirmed with solubility test, FT-IR, DSC and 1H-NMR.
方法：将乳糖化-去甲斑蝥素与磷脂聚合成药物磷脂复合物，并采用FT-IR、DSC和1H-NMR对其进行表征。
Methods: Lac-NCTD phospholipid complex was prepared using solvent-evaporation, and its correlated physicochemical properties were confirmed with solubility test, FT-IR, DSC and 1H-NMR.
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