相对于原癌基因和肿瘤抑制基因。
Contrast with proto-oncogene and with tumor-suppressor gene.
MGMT基因的失活常导致原癌基因的激活。
The inactivation of MGMT gene may urge the proto oncogene activation.
目的观察原癌基因表达在哮喘气道重塑中的作用。
AIM to explore the role of proto oncogenes in the process of airway remodeling in asthma.
目的探讨肝细胞凋亡与肝硬变及原癌基因的关系。
To study the relationship of hepatocyte apoptosis and gene expression of liver cirrhosis and primary hepatic carcinoma.
目的探讨原癌基因RET与先天性巨结肠发生的关系。
Objective To investigate the relationship between RET proto oncogene and the pathogenesis of Hirschsprung′s disease.
结论：MET原癌基因表达水平与食管鳞癌细胞分化相关。
Conclusion: The mRNA overexpression of MET proto-oncogene is correlated with tumor differentiation in ESCC.
同一种原癌基因在不同种动物生精周期的相同阶段表达也不尽相同。
In different kinds of animals, the same proto_oncogene showed different expressions in the same phase of spermatogenic cycle.
热休克蛋白可能有助于细胞周期调控通过与原癌基因的产品或抑癌基因的产品。
Heat Shock Proteins may contribute to cell cycle regulation by interacting with proto-oncogene products or tumor suppressor gene products.
目的：从基因水平了解正常胃和胃癌组织原癌基因和抑癌基因表达的分子机制。
Objective: To study the expressions of pro-onc and tumor suppressor genes in gastric cancer by cDNA expression array.
目的：探讨肝癌患者外周血淋巴细胞染色体脆性部位与原癌基因表达率的相关性。
Objective to explore the correlation between chromosome fragile site in peripheral blood lymphocytes and proto-oncogene expression rate in patients with hepatocellular carcinoma.
原癌基因的激活，抑癌基因的失活、突变，抗细胞凋亡等不同的机制都可能参与其中。
The different mechanisms, such as the activation of oncogenes, the inactivation and mutation of tumor suppressor gene, antiapoptosis and so on are involved in .
他们将原癌基因诱导的淋巴瘤移植到野生型小鼠，然后在淋巴瘤细胞启动p53表达。
They transplanted Myc-driven lymphoma cells into wild-type mice and then turned on p53 expression in the lymphoma cells.
肿瘤的发生是原癌基因激活、抑癌基因失活以及凋亡相关基因失调等诸多因素综合作用的结果。
The development of tumor results from complex action among multiple factors such as oncogene activation, anti-oncogene inactivation, disturbance of apoptosis related gene and so on.
虽然许多原癌基因和肿瘤抑制基因被广泛表达，这些基因的突变与特定的器官或细胞类型的癌有关。
Although many proto-oncogenes and tumor suppressor genes are widely expressed, the mutation of these genes is associated with cancer of specific organs or cell types.
方法应用PCRSSCP银染技术对30例先天性巨结肠原癌基因RET第17外显子进行检测。
Method Exon 17 of RET proto oncogene from 30 children with Hirschsprung's disease was detected by PCR SSCP method.
原癌基因的突变导致的过度刺激细胞周期，而突变的肿瘤抑制基因，会导致在这一功能的控制过度活动。
Oncogenes are mutations that cause an excessive stimulation of the cell cycle, while mutations in tumor suppressor genes can result in a loss in function in controlling this excessive activity.
这太有趣了，肿瘤基因（抑癌基因和原癌基因）的表达与多细胞生物体在遗传发生层面的形态协同一致的。
It is of interest that the coordinated expression of "cancer genes" (tumor supressors and oncogenes) coincides with the appearance of multicellularity in the filogenetic scale.
一般情况下，它们都处于封存不动状态，但在特殊情况下，原癌基因被激活或抗癌基因丢失，人就会患上癌症。
Under normal circumstances, they are sealed in a fixed state, but in exceptional circumstances, the proto-oncogenes or tumor suppressor genes are activated is lost, people will suffer from cancer.
氧化应激可以导致DNA链断裂、DNA位点突变、DNA双链畸变和原癌基因与肿瘤抑制基因突变等形式的DNA损伤；
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes;
AFP的作用均可被抗AFP单克隆抗体所拮抗 。实验结果提示 ，AFP对细胞生长的调节作用可能通过促进这些原癌基因的表达来实现 。
The effects of AFP could be blocked by anti AFP monoclonal antibody. The results indicated that AFP could regulate the growth of HeLa cells through enhancing the expression of these oncogenes.
强调了中医肿瘤病因的“三因”学说与基因组学中人类原癌基因活化的条件相一致；中医学“天人相应”学说与环境致癌、环境治癌及环境对基因表达的影响极为相似；
The author emphasizes that the theory of "three causes" for tumors is consistent with the conditions for the activation of human protooncogene in the science of genome.
强调了中医肿瘤病因的“三因”学说与基因组学中人类原癌基因活化的条件相一致；中医学“天人相应”学说与环境致癌、环境治癌及环境对基因表达的影响极为相似；
The author emphasizes that the theory of "three causes" for tumors is consistent with the conditions for the activation of human protooncogene in the science of genome.
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