MSC在肝内可演变为卵圆细胞、肝细胞及胆管细胞。
MSC can differentiate into oval cells, hepatocytes and biliary hepatocytes.
结果成功建立三种品系大鼠肝脏卵圆细胞增殖模型。
Results Hepatic oval cell proliferation models from three rat strains were successfully established.
此三型卵圆细胞均有细胞内张力微丝和细胞间连接结构。
Intracellular tonofilaments and intercellular junctions were seen in all three types of oval cells.
目的探讨卵圆细胞在进行性肝损伤过程中的分布及迁移规律。
Objective To explore the distribution and migration of oval cells in progressive hepatic injury.
现就肝卵圆细胞的定位、来源及调控机制的研究进展作一概述。
This review focuses on the location, origin and regulatory mechanism of HOC.
文章就肝卵圆细胞及其定向诱导分化为胰岛细胞的相关研究作一综述。
This article reviews the research progress of hepatic oval cells and differentiation into pancreatic cells.
目的对不同品系大鼠肝卵圆细胞增殖模型进行比较，筛选建模效率较高的大鼠品系。
Objective To select the rat strain relatively more suitable for model establishment by comparison of hepatic oval cell proliferation models from different rat strains.
肝卵圆细胞可以在体外诱导分化为胰岛细胞，因此可以作为胰岛细胞潜在的替代资源。
Hepatic oval cells can be induced in vitro to differentiate into pancreatic cells, and can sever as a potential alternative resource.
当肝脏发生严重损伤且肝细胞再生障碍时，卵圆细胞被激活并大量增殖，参与肝脏损伤的修复与重建。
Oval cells are activated to proliferate and regenerate liver tissue when the liver damage is extensive and chronic, or if proliferation of hepatocytes is inhibited.
结果卵圆细胞在培养过程中倍增时间逐渐缩短，非整倍体染色体数目增加，在软琼脂中生长的克隆增多。
Results During long term cultivation, the population doubling time of the cells became shorter and the percentage of aneuploidy chromosomes and colonies grown in soft AGAR increased.
目前的研究多对肝卵圆细胞进行活化、分离纯化、培养鉴定，再通过各种方法将其诱导分化为胰岛细胞。
The present researches were to active, separate, purify, cultivate and identify the HOCs, then all kinds of methods were used to induce it to differentiate into islet cells.
结论：与动物致癌模型肝中存在卵圆细胞一样，人肝细胞肝癌肝中也存在同样形态和免疫表型特点的卵圆细胞。
Conclusion Oval cells that exhibit the same morphologic and immunophenotypic features as those seen during animal hepatocarcinogenesis are found in human HCC.
结论在用于建立肝脏卵圆细胞增殖模型最为常见的三种品系大鼠中，F344大鼠所建模型的肝脏卵圆细胞活化效率最高。
Conclusion Among the three rat strains most commonly used for hepatic oval cell proliferation models, hepatic oval cells from F344 rats have the highest activation efficiency.
结论在用于建立肝脏卵圆细胞增殖模型最为常见的三种品系大鼠中，F344大鼠所建模型的肝脏卵圆细胞活化效率最高。
Conclusion Among the three rat strains most commonly used for hepatic oval cell proliferation models, hepatic oval cells from F344 rats have the highest activation efficiency.
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