动物实验证实协同刺激分子CD 80 (B7 - 1)是促进抗肿瘤免疫应答的重要分子。
A crucial role in eliciting anti-tumor immunity of costimulatory molecule CD80 (B7-1) has been demonstrated by animal experimental studies.
目的：分析过继转输的小鼠胚胎抗原耐受T细胞内细胞因子及细胞表面协同刺激分子的表达特征。
Objective: to explore the expression characteristics of intracellular cytokines and surface costimulatory molecules in embryo antigen tolerant t cells transferred in pregnant mice.
实验结果显示，4种协同刺激分子均参与虫卵肉芽肿的形成，尤其是B7 - 2和CD 40分子的作用更为显著。
The results show that the four co-stimulatory molecules anticipate the egg granuloma formation. Especially the effect of B7-2 and CD40 molecules are more significant.
第一信号为抗原与T细胞受体TCR的结合，第二信号为抗原递呈细胞上的协同刺激分子与T、B淋巴细胞上的受体结合。
The first signal is the binding of antigen with TCR on T cells. The second signal is the binding of co-stimulate on the APC with their receptors presenting on T and B lymphocytes.
第一信号为抗原与T细胞受体TCR的结合，第二信号为抗原递呈细胞上的协同刺激分子与T、B淋巴细胞上的受体结合。
The first signal is the binding of antigen with TCR on T cells. The second signal is the binding of co-stimulate on the APC with their receptors presenting on T and B lymphocytes.
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