他们已到了山穷水尽的地步，他们的生意再经受一次压力就会破产。
They are at the end of their tether; another strain upon their business means bankruptcy for them.
我终于到了山穷水尽的地步，几乎连应征广告的回信信封和邮票都找不到。
I was fairly at the end of my tether at last, and could hardly find the stamps to answer the advertisements or the envelopes to stick them to.
问题在于，除非旧体系已经到了山穷水尽的地步，新的体系是不会得到应用的。
The problem, he explained, was that an acceptable new process has yet to be put in place, and until one is, it would be impractical to jettison the old system.
我们见到的人已经到了山穷水尽的地步，他们正丧失一切：职业，亲属，家庭。
We see folks who have in bottom. They are losing everything: jobs, families, and homes.
所以，即便时局艰难，你觉得创意已经到了山穷水尽的地步，这并非没有希望再发挥创造力。
So, even when times are tough and your idea well seems like it's reached rock bottom, it doesn't mean all hope for creativity is lost.
到了如此山穷水尽的地步，这似乎也是非常自然的。
到了如此山穷水尽的地步，这似乎也是非常自然的。
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