一些通常在发育胚胎中活跃的基因会被分化细胞(比如皮肤细胞)表达,促使细胞回复到未分化状态。
A handful of genes that are normally active in the developing embryo are expressed in a differentiated cell, such as a skin cell, causing that cell to revert back to its undifferentiated state.
增加EGR1表达可以激活其他信号分子的转录,包括CDK5和酪氨酸羟化酶,对神经细胞生长和分化有长期影响(2,3)。
Increased EGR1 expression activates transcription of other signaling molecules, including CDK5 and tyrosine hydroxylase, and exerts long term effects on neural cell growth and differentiation (2, 3).
SATB1是一种由于在T细胞的分化和激活中调节相关基因表达起关键作用而广为人知的核内蛋白,它是免疫系统中的关键参与者。
SATB1 is a nuclear protein well known for its crucial role in regulating gene expression during the differentiation and activation of t cells, making it a key player in the immune system.
结论铁合金颗粒使成骨细胞OPG基因表达下降,使破骨细胞分化、活化功能增强,这可能是导致假体松动的骨溶解机制之一。
Conclusion Titanium alloy particles decrease expression of OPG gene in human osteoblasts, and this may contribute to the differentiation of osteoclasts which may lead to the periprosthetic osteolysis.
PKC是细胞信号传导途径中的一个中心环节,调节细胞的基因表达、生长发育及分化。
PKC is an important element of cellular signal transduction pathways that regulate cell growth, survival, differentiation and gene expression.
以免疫荧光法测定分化细胞神经特异性烯醇化酶(NSE)、星形胶质细胞特异性标志(GFAP)的表达。
The expression of NSE and GFAP in the differentiated cells was detected by immunofluorescence.
OSH1在此位置的表达表明此时期细胞已经开始分化了。
This localized expression of OSH1 indicates that the cellular differentiation has already occurred at this stage.
本文还讨论了细胞分化与细胞骨架及基因表达的关系。
Also the relationships of cell differentiation and cytoskeletal structure and gene expression were discussed.
为了理解单核细胞在这种状态下的基因表现,我们运用基因芯片的技术来调查单核细胞的分化的基因表达。
To understand the mononuclear cells in such a state of gene expression, we use gene chip technology to investigate the differentiation of monocyte gene expression.
目的:研究基质金属蛋白酶7基因(MMP 7)在胃癌组织及不同分化程度的胃癌细胞中的表达情况,探讨其临床意义。
Purpose: to study the expression of MMP 7 gene in gastric cancer tissue and different stomach cancer cell line and explore its clinical significance.
目的利用已经建立的胶质瘤细胞诱导分化相关基因表达谱,筛选胶质瘤恶性进展相关基因。
Objective To screen out genes associated with malignant progression of glioma, based on the established glioma cell differentiation-inducing gene expression profiles.
结论HPESCRG1基因是一个人类ES细胞中表达特异性新基因,很可能与人类ES细胞的自我更新和维持其未分化状态密切相关。
Conclusion HPESCRG1 was found to be a novel gene expressed specifically in human es cell, which might be related to self renewal of human es cell and maintaining its undifferentiated state.
结论:胰腺干细胞在分化过程中有细胞角蛋白19表达,细胞角蛋白19是胰腺干细胞的标志物。
CONCLUSION: Expression of cytokeratin 19 is observed during the differentiation of pancreas stem cells and cytokeratin 19 is a sign of pancreas stem cells.
目的:研究视神经损伤后神经胶质细胞去分化的程度及相关分子的表达。
Objective: To investigate the dedifferentiation of glia cells and the expression of related molecules after optic nerve injury.
结果CK19表达于有上皮异常增生的复层鳞状上皮基底上层和口腔鳞癌尤其是低分化鳞癌的癌细胞中。
Results CK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor differentiated cancerous cells.
研究表明,组蛋白的乙酰化与去乙酰化状态,可作用于T、B细胞的发育、分化、成熟、分泌及表面因子的表达等多个方面。
Studies had shown that acetylation and deacetylation of histone are of certain value on t, B cell's development, differentiation, maturation, secretion and surface factor's expression etc.
目的观察视黄酸对人横纹肌肉瘤细胞的诱导分化作用及对生肌调节因子(MRF)表达的影响。
Objective To study the effects of retinoic acid on the differentiation of human rhabdomyosarcoma cells and on the expression of myogenic regulatory factor (MRF).
目的:探讨系统性红斑狼疮(SL E)患者疾病活动期和非活动期各种免疫细胞系列分化抗原表达的变化。
Objective to study the expressions of immune cell differentiation antigens in patients with active and inactive stages of systemic lupus erythematosus (SLE).
不同分化阶段的白血病细胞表达NS基因水平存在着差异。
There is difference among the expression level of NS gene in the leukemic cells of different differentiation stage.
目的建立诺帝诱导人胶质瘤细胞系CHG - 5分化的蛋白质表达图谱并比较其表达差异。
Objective To establish the protein expression profile of human glioma cell line CHG-5 differentiation induced by Nordy and identify the differentially expressed proteins.
目的:探讨P27蛋白在不同分化程度星形细胞瘤组织中的表达,并进行相关因素分析。
AIM: to investigate and analysis the expression of P27 protein in brain astrocytoma with various grades of differentiation.
分化后的细胞表达神经元细胞、质细胞和少突胶质细胞的特异性抗原。
Mature neural cells after differentiation could express specific antigens of neuron, astrocyte and oligodendrocyte.
目的:观察上皮型钙粘蛋白在小鼠胚胎干细胞体外分化过程中的动态表达,及其与细胞间黏附状态的关系。
OBJECTIVE: To observe the dynamic expression of E-cadherin in embryonic stem cell differentiation and the effect on cell adhesion.
PDGF的过度表达与肿瘤细胞的分化程度无关。
There were no correlation between PDGF overexpression and the degree of cell differentiation.
目的探讨脑肿瘤干细胞(BTSC)在体外分化过程中的细胞形态、分化相关标志物表达和增殖动力学变化,为进一步研究BTSC分化走向提供实验依据。
Objective To pursue the changes of cell morphology, expression of differentiation related markers, and proliferation cycles of brain tumor stem cells (BTSCs) after differentiation in vitro.
目的观察地塞米松调节人卵巢癌细胞系3ao细胞增殖分化的作用机制及3ao细胞中糖皮质激素受体(GR)的表达。
Objective to study the effects of dexamethasone on the proliferation and differentiation of a human ovarian carcinoma cell line (3ao) and on the expression of glucocorticoid receptor (GR).
LMP可明显抑制DMSO对CNE1细胞的诱导分化作用,转染细胞诱导后增殖力和角蛋白表达无显著改变(P>0.05)。
The differentiation of CNE1 cells induced by DMSO was inhibited by LMP, there were no changes on the proliferation and keratin expression after induction of cells transfected by LMP gene ( P >0 05).
目的研究二烯丙基二硫(DADS)诱导人髓性白血病HL - 60细胞分化过程中蛋白质组的差异表达。
Objective To study differential proteomic expression in the differentiation of HL-60 cells induced by diallyl disulfide (DADS).
目的研究二烯丙基二硫(DADS)诱导人髓性白血病HL - 60细胞分化过程中蛋白质组的差异表达。
Objective To study differential proteomic expression in the differentiation of HL-60 cells induced by diallyl disulfide (DADS).
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