目的研究人早期胚胎分割后单个卵裂球的继续发育与分化,探讨人早期胚胎卵裂球的全能性。
Objective: to investigate the development and differentiation of blastomeres isolated from early human embryos, and study the totipotency of blastomeres.
背景:人胚胎干细胞传代培养的关键是抑制其自发分化、保证细胞的全能性。
BACKGROUND: Key point for subculture of human embryonic stem cells is to inhibit spontaneous differentiation and make sure totipotency of cells.
胚胎分割是研究细胞分化、早期胚胎发育、胚胎细胞全能性的有力手段。
Embryo bisection is a powerful means in the study of cell differentiation, early embryonic development and the totipotency of embryo cell.
目的:人胚胎干细胞传代培养的关键是抑制其自发分化、保证细胞的全能性。
AIM: the key of the human embryonic stem cell culture is to guarantee the totipotency and inhibit spontaneous differentiation.
对于干细胞来说,时间是关键。为了维持分化的全能性,需要一种分子机制,将细胞维持在自我更新的状态直到这些干细胞被邻近组织需要。
For stem cells, timing is key: To maintain their versatility they rely on a molecular mechanism that keeps the cells in a state of self-renewal until they are needed by adjacent tissue.
对于干细胞来说,时间是关键。为了维持分化的全能性,需要一种分子机制,将细胞维持在自我更新的状态直到这些干细胞被邻近组织需要。
For stem cells, timing is key: To maintain their versatility they rely on a molecular mechanism that keeps the cells in a state of self-renewal until they are needed by adjacent tissue.
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