方法将12只雄性SD大鼠随机分为对照组和内毒素组。
Methods 12 male SD rats were randomly divided into control group and endotoxin group.
另设正常动物注射内毒素组和甘氨酸拮抗内毒素组加以对照。
The normal rats injected with LPS or injected with LPS combined with glycine (LPS antagonist) were designed as controls.
用大肠杆菌内毒素（LPS）复制大鼠内毒素性休克模型，氨基胍治疗组采用氨基胍治疗。
Rats were challenged by E. coli LPS to set up the model of endotoxic shock, AG group were treated by aminoguanidine.
内毒素含量的测定：两组内毒素水平在0H，8H和24H时相均有显著差异（P<0.01）。
The evalument of endotoxin content: endotoxin level in 2 groups is significantly different in 0H, 8H and 24H three phases (P<0.01).
HMGB1蛋白水平于内毒素注射后1 h无明显升高，至24 h两组均显著升高，后呈缓慢下降趋势。
And the plasma level of HMGB1 obviously elevated in both group 24 hour after the endotoxin injection, then started to drop slowly.
HMGB1蛋白水平于内毒素注射后1 h无明显升高，至24 h两组均显著升高，后呈缓慢下降趋势。
And the plasma level of HMGB1 obviously elevated in both group 24 hour after the endotoxin injection, then started to drop slowly.
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