该嵌段共聚物微球能提高蛋白、多肽的稳定性,有利于难溶性药物释放。
The microspheres of PEG-PLA block copolymers can enhance the stability of protein and polypeptide, and profit the release of poorly water-soluble pharmaceuticals.
目的考察乳酸-羟乙醇酸共聚物(PLGA)微球制备工艺对新城疫病毒的稳定性影响,并寻求合适的保护剂以稳定新城疫病毒的活性。
OBJECTIVE to evaluate the effects of formulation technique of PLGA microspheres on the stability of Newcastle disease virus and to look for a proper protectant to stabilize Newcastle disease virus.
介绍PLA -PEG嵌段共聚物的合成和性质,综述其作为胶束、微球、纳米粒等的载体在药物释放系统中的应用。
Syntheses and properties of PLA-PEG block copolymers were introduced, and their applications for micelles, microspheres and nanoparticles in drug delivery system were also reviewed.
二种组成比不同的丙交酯—乙交酯共聚物以溶剂挥发法制成含炔诺酮的微球。
The different lactide-co-glycolide ratio of the PLGA microspheres containing NET was prepared by a solvent-evaporation process.
方法:以鸡新城疫病毒(NDV)作为疫苗模型药物、乳酸-羟基乙酸共聚物(PLGA)为载体材料,采用W/O/W复乳-溶剂挥发法制备NDV-PLGA口服微球。
METHODS:Newcastle dis-ease virus(NDV)vaccine was used as model drug, and PLGA as carrying agent to prepare NDV-PLGA oral microspheres by W/O/W emulsifying-solvent evaporation technique.
方法:以鸡新城疫病毒(NDV)作为疫苗模型药物、乳酸-羟基乙酸共聚物(PLGA)为载体材料,采用W/O/W复乳-溶剂挥发法制备NDV-PLGA口服微球。
METHODS:Newcastle dis-ease virus(NDV)vaccine was used as model drug, and PLGA as carrying agent to prepare NDV-PLGA oral microspheres by W/O/W emulsifying-solvent evaporation technique.
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