天然产物是药物先导化合物的重要来源。
Natural products are one of the most important sources of the lead compounds in drug discovery.
通过三维数据库搜索可能会得到新的先导化合物。
And some lead compounds may be acquired through three-dimensional database searching.
天然产物的结构修饰是发现先导化合物的重要途径。
Structure modification of natural products is an important way to discover lead compounds.
开发出一批具有新颖结构的黄酮类药物的先导化合物。
This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
现在分子阵列已经成功应用于蛋白分析、先导化合物的发现等许多领域。
They have already been successfully applied in important areas ranging from protein profiling to the discovery of therapeutic leads.
意义该项目将发现有前途的药物先导化合物，阻断黄病毒家族的病毒复制。
This project will discover promising drug leads that stop the replication of viruses within the Flaviviridae family.
以蝙蝠葛碱为先导化合物，采用Q型信息群分法，进行计算机辅助系列设计。
Dauricine was taken as a lead compound and the Q-model information cluster analysis was employed for the computer-aided molecular design.
因此以经典肽为活性先导化合物进行结构改造成为开发新药的理想途径之一。
Therefore, structure modification of classical peptide becomes a preferable way for drug research and development.
因此，7 -甲氧基黄酮及衍生物很有可能成为新型结构的抗癌先导化合物。
Therefore, 7-methoxy flavone and its derivatives can be promising antitumor lead compounds.
本发明可为研制新的抗肿瘤药物提供先导化合物，可望成为治疗癌症的药物。
The invention can provide lead compounds for the development of new anti-cancer drugs and is expected to become the drugs for cancer treatment.
目的确定可靠的筛选小分子人白介素6 (IL 6)受体拮抗剂先导化合物的细胞模型。
AIM to confirm R2 cells being reliable cell model to screen small molecular human interleukin-6 (IL-6) receptor antagonists.
当代药物设计是通过阐明药物与靶标相互作用的机理，对药物先导化合物进行改造和优化。
Drug design is based on the mechanisms of the drug and target interaction to achieve optimization of the leads.
本文在前人研究的基础上，以PHR0007为先导化合物，按着新药设计原理合成了10个未见文献报道的化合物。
In this paper, according to the principles of new drug design, On the basis of former research the 10 compounds guided by the lead compound PHR0007 were synthesized.
该文综述了这一领域的主要进展及其在药物研究与开发（如先导化合物的发现和新型诊断与治疗方法的设计）中的应用。
Progress in the field is briefly reviewed and possible application of evolutionary chemistry in drug research and development such as discovery of lead compounds and des…
对核苷类化合物糖环部分的化学改造一直是发现新的具有抗病毒、抗肿瘤或其他生物活性的核苷类先导化合物的重要途径之一。
The chemical modification of sugar moiety in nucleoside or nucleotide is always an important way to discover new lead compounds with anti-viral, anti-tumor and other biological activities.
其次，以白杨素为先导化合物对其进行磺化，得到两种白杨素磺化物：白杨素-6-磺酸钠和白杨素-8-磺酸钠的混合物，通过络合解聚使其分离。
Secondly, the mixture of chrysin-6-sulfonate and chrysin-8-sulfonate was obtained by sulfonated chrysin. By the method of coordination and depolymerization, two chrysinsulfonates were separated.
本文用支持矢量学习机和神经网络两种机器学习方法建立选择性环氧化酶-2抑制剂的活性预测模型，以期为选择性环氧化酶-2抑制剂药物的合成提供先导化合物。
Machine learning methods, including Support Vector Machines and Artificial Neural Network, are applied to the development of the classification models for the selective COX-2 inhibitors in this paper.
在1981～2002年间批准上市的1 031种药物中，有48％的药物来源于天然产物或与天然的先导结构有关，其中5％的药物为天然化合物的直接应用。
Of the 1 031 new chemical entities covering all diseases in the years 1981-2002, 48% were natural product mimics, 5% were the direct ultility of natural products as sources of novel structures.
以天然有机化合物为先导，利用半合成法对其进行结构修饰和改性，是发现新的疗效成分和新药开发一个重要途径。
It is an important approach to find new medical components and to develop new drugs by modifying the structure of natural product.
独特，调节先导救济行动与有能力处理好热水，蒸汽，热水的碳氢化合物蒸气或液体，使用惰性塑料软商品软座椅阀。
Unique, modulating action pilot operated relief valve with soft seats having the ability to handle hot water, steam, hot hydrocarbon vapors or liquids, using inert plastic soft goods.
独特，调节先导救济行动与有能力处理好热水，蒸汽，热水的碳氢化合物蒸气或液体，使用惰性塑料软商品软座椅阀。
Unique, modulating action pilot operated relief valve with soft seats having the ability to handle hot water, steam, hot hydrocarbon vapors or liquids, using inert plastic soft goods.
应用推荐