结论苯中毒患者外周血白细胞的DNA复制及损伤修复基因与正常人相比存在差异性表达，为进一步筛选苯中毒生物标志物提供了依据。
Conclusions Some DNA replication, and damage repair genes associated with benzene poisoning show differential expression, which provides the basis for screening biomarkers of benzene poisoning.
目的探讨晚期非小细胞肺癌(NSCLC)组织中DNA修复基因家族成员ERCC1、RRM1和BRCA1的表达及其临床意义。
Objective To investigate the expression of DNA repair gene family members of ERCC1, RRM1 and BRCA1 in tissues of advanced non-small cell lung cancer (NSCLC), and explore its clinical significance.
目的：探讨核苷酸切除修复基因ERCC1在肺癌中的表达及其与多环芳烃(PAH) -DNA加合物的关系。
AIM: To investigate the expression of nucleotide excision repair gene ERCC1 and its relationship with PAH (polycyclic aromatic hydrocarbons) -dna adducts in lung cancer tissues.
目的运用低密度表达谱芯片检测人脑原发胶质瘤组织中DNA损伤修复基因的表达情况，进一步分析其表达变化的意义。
Objectives to detect the expression of DNA repair genes in primary glioma tissues by low-density array, and to analyze the significance of the expression.
砷可能通过抑制砷中毒患者皮肤组织中MGMT、XRCC1等DNA修复基因的表达，影响基因组d NA稳定性和DNA修复功能而导致对皮肤的致癌作用。
Arsenic causes carcinogenicity on human skin through inhibiting the expressions of MGMT, XRCC1 and influencing the genetic stability and the DNA repair function.
结论CRLP基因的表达受到抑制以后可能通过影响细胞DNA修复能力降低细胞抗紫外杀伤的能力。
Conclusion Inhibition of CRLP may reduce the DNA repair ability through blocking DNA repairing complex forming.
抑癌基因p53编码转录因子p53蛋白在调控癌基因表达、dna合成和损伤修复以及细胞凋亡中起关键作用。
The tumor suppressor gene p53 codes for a transcription factor, p53 protein, plays a critical regulation role in oncogene expression, DNA synthesis and repair systems, and cell apoptosis.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
结果基因芯片分析显示，HGC27细胞的64对核修复相关基因中，12对基因表达水平下调至0.5以下，6对基因表达水平上调至2倍以上。
Results The cDNA microarray results indicated that 12 out of 64 DNA repair related genes in HGC27 cells were down-regulated (inferior to 0.5 fold) and 6 genes was up-regulated (superior to 2 folds).
一旦TP53蛋白被激活就能引发数种基因的表达来影响细胞周期阻滞、DNA修复、或者在DNA修复失败后引导凋亡发生。
Once the TP53 protein is activated, it can trigger the expression of several genes that influence cell cycle arrest and DNA repair or lead to apoptosis when DNA repair is failed.
结论：大鼠股骨骨不连中心区在修复早期BMP2基因的低表达及表达时间滞后可能是其骨不连发生的原因之一。
Conclusion: Lower value and the lag in genic expression of BMP2 in the central zone during the early stage may be an important reason of nonunion occurring in rat femur.
结论：大鼠股骨骨不连中心区在修复早期BMP2基因的低表达及表达时间滞后可能是其骨不连发生的原因之一。
Conclusion: Lower value and the lag in genic expression of BMP2 in the central zone during the early stage may be an important reason of nonunion occurring in rat femur.
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