无论是tasocitinib还是Incyte的药物，INCB 028050，都是目标直指激酶，通过一种叫做细胞因子的免疫系统蛋白介导信号。
Both tasocitinib and Incyte's drug, INCB028050, target Janus kinases, which mediate signalling by immune-system proteins called cytokines.
这些药物的作用机制是阻断酪氨酸激酶启动信号级联反应，后者可以促进肿瘤细胞生长。
The drugs work by preventing an enzyme called tyrosine kinase from launching a signaling cascade that fuels tumor cell growth.
蛋白质激酶的磷酸化级联放大系统在激素的信号转导中起重要作用。
Signalling cascades consisting of protein kinases play important roles in hormone signal transduction pathways of plants.
目的探讨急、慢性铅中毒对大鼠海马活化的细胞外信号调节激酶2 (ERK2)含量的影响及其与海马CA 1区长时程增强(ltp)的关系。
AIM To investigate the effect of acute and chronic lead exposure on CA1 long term potentiation (LTP) and active extracellular signal regulated kinase 2 (ERK2) of rat hippocampus.
目的探讨急、慢性染铅对大鼠海马总量细胞外信号调节激酶2 (ERK2)含量的影响。
Objective to study the effect of acute and chronic lead exposure on total extracellular signal regulated kinase 2 (ERK2) of rat hippocampus.
目的探讨经皮穿刺激光心肌血管重建术(PTMR)后细胞外信号调节激酶的动态变化。
Objective To investigate dynamic alternation of extracellular signal regulated kinases induced by percutaneous transluminal myocardial laser revascularization (PTMR).
结论CD 117可作为MM的肿瘤相关抗原，也可作为靶向信号转导抑制剂酪氨酸激酶选择性抑制剂应用的有价值的标志。
CONCLUSION: CD117 can be regard as the related tumor antigen of MM, and may be a valuable marker in the use of tyrosine kinase selective inhibitors, which inhibit the signal conduct to the target.
属于酪氨酸激酶受体，可以传递表皮生长因子家族的信号。
The family of ErbB tyrosine kinase receptors can transmit signals derived from growth factor of epidermal growth factor family.
这种形状上的变化将通常状况下无活性的激酶转变为活性形式，随后将能够激发细胞生长的信号传递到胞内。
This change of shape converts the normally inactive kinase into an active one, which then sends signals inside the cell that trigger cell growth.
目的研究胃泌素对人结肠癌细胞信号分子黏着斑激酶(FAK)酪氨酸磷酸化和蛋白质表达的影响。
Objective the study investigated the effect of gastrin on tyrosine phosphorylation and protein expression of focal adhesion kinase (FAK) in human colon cancer cells.
探讨细胞外信号调节激酶(ERK)在卵巢上皮性肿瘤组织中的表达及其意义。
To investigate the expression of extracellular signal-regulated kinase (ERK) and its significance in epithelial ovarian tumor.
丝裂原激活的蛋白激酶又称细胞外信号调节激酶，具有神经元信号传导功能，参与多种发育过程。
Mitogen activated protein (MAP) kinase, also known as extracellular signal regulated kinase, or ERK, functions in neuronal signal transduction and participates in diverse development processes.
目的：研究pten、细胞外信号调节激酶(ERK)表达及与舌鳞状细胞癌(TSCC)临床病理参数的关系。
Objective: to study the expressions of PTEN and extracellular signal-regulated kinase (ERK) and their clinical significance in tongue squamous cell carcinoma (TSCC).
受体酪氨酸蛋白激酶是细胞信号转导进行的关键信号酶，在生长因子调控细胞生长、发育与功能的过程中起着重要的生理作用。
Receptor tyrosine protein kinase is one of key kinases in cell signal transduction and plays an important role in the process of cell growth, development and functions regulated by growth factors.
目的探讨辛伐他汀对自发性高血压大鼠（SHR）心肌肥厚及细胞外信号调节激酶（ERK）的影响。
OBJECTIVE To explore the effect of simvastatin on myocardial hypertrophy and the expression of extracellular signal-regulated kinases (ERK) in spontaneously hypertensive rat (SHR).
特异的信号基序不仅包括蛋白激酶可以识别的序列(1)，也包括那些能够被磷酸化依赖结合蛋白如14-3-3识别的序列(2)。
Specific signaling motifs include not only sequences that are recognized by protein kinases (1), but also those that are recognized by phosphorylation-dependent binding proteins such as 14-3-3 (2).
并非肼屈嗪而是缬沙坦能够防止神经与凋亡，他的作用与其抑制细胞凋亡信号调节激酶1的活性有关。
Valsartan, but not hydralazine, prevented neuronal apoptosis, being associated with the suppression of apoptosis signal-regulating kinase 1 activation by valsartan.
目的：研究细胞外信号调节蛋白激酶（ERK）信号通路在癫痫大鼠脑内的表达规律及其意义。
Objective: To investigate the expression of extracellular signal regulated protein kinase(ERK) signal transduction pathway and its significance in the rat brain after epileptic seizures.
吉非替尼为一种选择性的EGFR一蛋白酪氨酸激酶抑制剂，能阻断酪氨酸蛋白激酶信号传导通路，从而促进肿瘤细胞凋亡。
Gefitinib is protein tyrosine kinase inhibitor of a selective EGFR, can block the signal transduction pathway of tyrosine protein kinase, and then promote tumor cell apoptosis.
结论：针刺能刺激大鼠胃黏膜细胞信号转导通路中蛋白激酶c的活化，并且存在经脉-脏腑的特异性联系。
CONCLUSION: the acupuncture can stimulate the activation of PKC in gastric mucous cell signal conductive pathway of rats, and there is a special correlation between meridian and internal organs.
蛋白质的可逆磷酸化过程在细胞的信号识别与转导中起重要作用，蛋白激酶主要催化蛋白质的磷酸化作用。
The reversible phosphorylation of protein kinase plays important roles in many signal identifying and transfer in cell. The protein kinases mainly catalyse phosphorylation of proteins.
目的探讨细胞外信号调节激酶（ERK）在NGF诱导的PC12细胞分化中的作用机制。
Objective To decide whether the extracellular signal-regulated kinase (ERK) play a crucial role in PC12 differentiation induced by nerve-growth factor (NGF).
目的：研究前列腺癌进展中细胞丝裂原活化蛋白激酶（MAPK）信号通路的变化，探讨阻断此通路对前列腺癌细胞增殖的影响。
To investigate the change of mitogen activated protein kinase(MAPK) signaling pathway during prostate cancer progression, and therefore to explore its role on cell proliferation.
蓝藻信号转导系统主要包括二元信号转导系统和丝氨酸/苏氨酸激酶。
The signal transduction system of cyanobacteria is constituted of two-component signal transduction system and eukaryotic-type serine/threonine kinases.
目的细胞外信号调节激酶(ERK)与细胞生长，分化，增殖等生理病理过程有密切关系。
Objective Extracellular signal-regulated kinase (ERK) is closely related to cellular growth, differentiation and proliferation.
细胞外信号调节激酶信号通道是一条重要的细胞内传导通道。
Extracellular signal-regulated kinase (ERK) signaling pathway is a critical signaling pathway that transduce the intracellular signal.
组氨酸激酶在高等植物中广泛存在，是双组分信号系统的重要元件。
Histidine kinases are widely existed in higher plants and are important components of two-component signal transduction systems.
目的研究血小板源生长因子(PDGF)对肾小球系膜细胞(MC)表型转化的影响，并探讨丝裂素活化蛋白激酶(MAPK)信号转导途径在其作用中的调控机制。
Objective to investigate effects of PDGF on phenotypic change of glomerular mesangial cells (MC), and study intracellular mechanisms through mitogen-activated - protein kinase (MAPK) pathways.
细胞外信号调节激酶是丝裂原激活蛋白激酶家族的重要成员。
The extracellular signal-regulated kinase(ERK) is an important member of mitogen-activated protein kinase(MAPK) family.
细胞外信号调节激酶是丝裂原激活蛋白激酶家族的重要成员。
The extracellular signal-regulated kinase(ERK) is an important member of mitogen-activated protein kinase(MAPK) family.
应用推荐