通常源于种系的新突变或体细胞突变。
结果发现4例体细胞突变均有临床效应；
Results: Observation 4 cases with somatic mutation have clinical effect.
体细胞突变是柑橘等果树比较常见的生物学现象，也是品种选育，即芽变选种的主要变异来源。
Somatic mutation, a main biological phenomenon of citrus and other fruits, is often used for breeding as a major variation source. Spontaneous mutations often occur in citrus.
在M_1所产生的叶绿素缺失中，大多数属于体细胞突变，或是由于辐射损伤所致，一般是不能遗传的；
Most of the chlorophyll deletion occurred in M1 were belonged to somatic mutation or caused by radiation injury so that they usually were not inheritable.
在这里，我们调查的，是由体细胞突变引起的肿瘤细胞的细胞核，能被后生重编程进入正常组织的可能性。
Here, we investigate the possibility of whether a tumor cell nucleus, in which transformation is caused by somatic mutation, can be epigenetically reprogrammed into normal tissues.
该药物能够准确的将正确的染色体数目导入每一新细胞，产生非整倍体细胞，能够用于治疗由于肿瘤抑制基因突变导致的肿瘤。
Drugs that inhibit accurate delivery of the right number of chromosomes to each new cell, resulting in aneuploidy, would be used to destroy tumors caused by mutations in the tumor suppressors.
目的探讨乳腺癌的线粒体基因D环区的体细胞性突变和多态性变异特征。
Objective To investigate the features of somatic mutations and polymorphisms of mitochondrial D loop regions in breast cancer.
此外，体细胞点突变与特定临床特征及预后相关。
Moreover, somatic point mutations were associated with specific clinical features and prognosis.
目的：探讨表皮生长因子受体(EGFR)基因酪氨酸激酶域体细胞在肺腺癌患者中突变的相关因素。
Objective: to study Somatic mutation of the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR gene) in lung adenocarcinoma patients.
采用体细胞连续定向筛选技术，结合体细胞诱变技术，获得非转基因抗草甘膦的棉花突变体—r 1098。
A cotton mutant, R1098 with the trait of resistance to glyphosate, was obtained by the method of somatic cell inducing and continued directional selection.
由于人体细胞的无义突变也可能敏感于反义试剂的抑制作用，这就为治疗由于无义突变导致的多种疾病提供了一个新途径。
Nonsense termination in human cells may also be susceptible to suppression by antisense agents, providing a new approach to address numerous diseases caused by nonsense mutations.
目的：初步鉴定宽叶菘蓝体细胞无性系植株的抗病突变体。
Objective: To make initial identification on Isatis Indigotica Somatic Clones' resistant mutant.
为毒素液应用于抗病资源的快速筛选与鉴定、体细胞抗性突变体的筛选等研究提供了可靠的参考资料。
The possible application of toxic filtrates on the selection of resistant resources and resistant cell lines was also discussed.
结论TTGE是筛选线粒体基因体细胞性同质性突变和各种比例异质性突变的一种敏感方法。
Conclusion TTGE is an effective method for screening acquired homoplasmic mitochondrial gene mutation and its different percentage.
基因突变使得人体细胞不再产生正常的CCR5蛋白质，HIV病毒因此也就没有了可以进入人体细胞的载体。
Gene mutation makes human cells no longer produce normal CCR5 protein, HIV virus so it can not enter the human cell carrier.
在10个基因中发现频发突变，通过与口腔拭子中的基因组d NA比较分析这些突变的体细胞特征。
Recurrent mutations were found in 10 genes and the somatic nature of these mutations was analyzed by comparison with generic DNA from buccal swabs.
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP与CTCF）的基因。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP与CTCF）的基因。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
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