波替单抗(万珂)是第一个进入临床试验的蛋白酶体抑制剂。
Bortezonib (velcade) is the first proteasome inhibitor that has entered clinical trial.
目的：研究泛素蛋白酶体抑制剂对胃癌细胞增殖和凋亡的影响。
AIM: to investigate effects of ubiquitin-proteasome inhibitor on proliferation and apoptosis of gastric carcinoma cells.
蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡，逆转多药耐药。
Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.
用蛋白酶体抑制剂抑制可以明显阻断肌细胞MHC I分子的表达；
The expression of MHC I molecules on the muscle cells can be inhibited by the proteasome inhibitors lactacystin and MG132.
目的研究蛋白酶体抑制剂PSI诱导PC12细胞胞浆内嗜酸性包涵体的形成及演变过程。
Objective To study the formation and development of inclusions in dopaminergic PC12 cells treated with proteasome inhibitor PSI.
目的探讨蛋白酶体抑制剂MG- 132对体外人u87胶质瘤细胞增殖和凋亡的影响。
Objective to explore the effects of proteasome inhibitor MG-132 on proliferation, apoptosis of U87 glioma cells in vitro.
一些有前景的药物如沙利度胺、蛋白酶体抑制剂、砷剂等的应用使MM的治疗得到了极大的突破。
Applications of several perspective drugs such as Thalidomide, proteasomes inhibitor, arsenical and other agents bring galactic breakthrough to the treatments of MM.
进而，采用流式细胞技术研究了不同蛋白酶体抑制剂以及TAP对噬菌体颗粒抗原交叉呈递的影响。
Furthermore, the effect of proteasome inhibitors and TAP on particle antigens cross presentation was investigated by FACS analysis.
蛋白酶体抑制剂MG- 132可以减轻高氧引起的肺损伤，可能对p 38 MAPK信号通路有抑制作用。
The proteasome inhibitor MG-132 can reduce the lung injury induced by hyperoxia and inhibit P38MAPK signaling pathway.
综述了有机硼酸类化合物作为酶抑制剂的研究进展，重点介绍了近年来发现的丝氨酸蛋白酶抑制剂、蛋白酶体抑制剂和精氨酸酶抑制剂。
The recent progress of boronic acid derivatives used as enzyme inhibitors is reviewed focused on the serine protease inhibitors, proteasome inhibitors, and arginase inhibitors.
结论：蛋白酶体抑制剂mg132能够抑制多巴胺能细胞PC 12的增殖并诱导细胞凋亡，蛋白酶体活性的丧失可能影响到多巴胺能细胞的生存。
CONCLUSION: MG132 can inhibit the proliferation of dopaminergic PC12 cells and lead to apoptosis. The disfunction of proteasome may do harm to the existence of dopaminergic cells.
本论文综述回顾了近几年前体加工酶及其抑制剂研究领域的一些新进展。
The thesis reviews some recent progresses and developments in the study of PCs and their inhibitors.
甾体芳香酶抑制剂能抑制芳香酶活性，阻断芳构化反应，抑制雌激素生成，从而达到治疗乳腺癌的目的。
Steroidal aromatase inhibitor can inhibit the aromatase activity, interdict the reaction, and inhibit the estrogen formation, so that it can cure the breast cancer.
其研究结果将为合理设计新型顶体酶抑制剂，寻找男性口服避孕药奠定坚实基础。
These results provided a basis for the rational design of specific inhibitors to the target enzyme and the discovery of novel contraceptive agents with high potency.
其他被认可的治疗免疫性血小板减少性紫癜病的手段包括：甾体类药物，免疫抑制剂类药物，或者通过外科手术切除患者的脾脏。
Janet Woodcock , head of the FDA's Center for Drug Evaluation and Research. Other approved ITP treatments include steroids, immune-suppressing drugs or surgery to remove the spleen.
直到1980年，只有其中的一种病毒被注册作为一种抑制剂，是一种植物松毛虫细胞质多面体病毒。
Until 1980 only one of these viruses was registered as a control agent, a CPV of the pine caterpillar Dendrolimus spectabilis.
Slentrol是一种新型化学物质，选择性微粒体甘油三酸酯转移蛋白抑制剂，阻断脂蛋白在血液中的合成和释放。
Slentrol is a new chemical entity called a selective microsomal triglyceride transfer protein inhibitor, which blocks the assembly and release of lipoproteins into the bloodstream.
本文对蛋白酶体的组成结构、病理生理作用和现有抑制剂进行归纳总结。
This review summarizes composition and structure of proteasome, its physiological and pathological actions, and available inhibitors.
艾司奥美拉唑是一种新型的质子泵抑制剂， 它是奥美拉唑的S-型光学异构体。
Esomeprazole, a new proton pump inhibitor, is the S - isomer of omeprazole.
丙二酸辅酶A脱羧酶（MCD ）抑制剂类似的有益效果还体现在受需求诱导的猪在体心脏方面。
Similar beneficial effects of MCD inhibition are seen in the in vivo pig heart subjected to a demand-induced ischemia.
细胞渗透、有效的蛋白磷酸酶抑制剂。凋亡诱导剂。两种异构体的混合物。
Cell permeable, potent protein phosphatase inhibitor. Apoptosis inducer. Mixture of two isomers.
采用丝氨酸内肽酶抑制剂和植物生长调节剂处理离体黄瓜叶片，研究了黄瓜叶片暗诱导衰老过程中丝氨酸内肽酶的作用。
The role of serine endopeptidase in cu-cumber leaf senescence was studied by using the inhibitor of serine endopeptidase and plant growth regulators(6-BA and ABA)on darkness-induced cucumber leaves.
采用丝氨酸内肽酶抑制剂和植物生长调节剂处理离体黄瓜叶片，研究了黄瓜叶片暗诱导衰老过程中丝氨酸内肽酶的作用。
The role of serine endopeptidase in cu-cumber leaf senescence was studied by using the inhibitor of serine endopeptidase and plant growth regulators(6-BA and ABA)on darkness-induced cucumber leaves.
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