然而低氧诱导VEGF分泌的细胞内信号转导机制还不是很清楚。
Nevertheless, the intracellular signaling mechanisms of hypoxia-induced VEGF release remain largely unknown.
在此综述中，我们总结并讨论了有关低氧诱导因子干预不同血管重建过程的机制。
In this review, we summarize and discuss mechanisms by which HIF interferes with the different vascular remodeling processes.
转录因子低氧诱导因子1（HIF1）已被证明可以调节多个参与代谢活动的基因。
The transcription factor hypoxia-inducible factor 1 (HIF1) has been implicated in regulating many of the genes that are responsible for the metabolic difference.
低氧可激活低氧诱导因子(HIF - 1)，从而调控一系列与缺氧相关基因的表达。
Hypoxia activates hypoxia-inducible factor 1 (HIF-1), thus it controls a series of expression of genes correlated with hypoxia.
低氧诱导因子1 (HIF - 1)是重要的氧依赖性核转录因子，低氧条件下能上调多个靶基因表达以减少缺氧性损伤。
Hypoxia inducible factor-1 (HIF-1) is a key oxygen-dependent transcription factor that up-regulates many protective genes against hypoxia-induced injury.
为研究低氧诱导因子- 1 (HIF - 1)在小鼠胚胎神经胚形成阶段的时空表达规律，探讨HIF - 1在胚胎神经系统发生和发育过程中的作用。
To investigate the spatiotemporal expression of hypoxia-inducible factor-1 (HIF-1) during murine neurulation and explore the role of HIF-1 in the embryonic development of the nervous system.
一种被称为缺氧诱导因子蛋白的特殊蛋白，控制帮助低氧条件下生存的基因。低氧的区域通常产生肿瘤的快速生长。
A specific protein, called the hypoxia-inducible factor protein, controls genes that help calls survive under low-oxygen conditions. Areas of low oxygen are common for fast-growing tumors.
低氧条件会直接诱导丙酮酸脱氢酶激酶1 (PDHK1)的表达，它的表达会抑制pdh的活性和TCA循环，从而抑制了随后的代谢通路(4)。
Hypoxia can directly induce pyruvate dehydrogenase kinase 1 (PDHK1) expression, which results in inactivation of PDH and the TCA cycle and subsequent suppression of metabolism (4).
但是，慢性低氧肺动脉高压大鼠5-HT诱导的血管收缩反应是通过5 - HT _ (2 A)和5 - HT _ (1 B)受体介导的。
However, in hypoxic pulmonary hypertension rats, 5 - HT - induced vasoconstriction is mediated by both the 5 - HT1Band 5 - HT2A receptor.
结论慢性低氧高二氧化碳诱导了大鼠支气管血栓素合酶基因的表达。
Conclusion The expression of TXS gene in bronchi was induced by chronic hypoxia and hypercapnia.
结论：高原缺氧诱导了VEGF分泌增多，VEGF在HAPC的肺动脉高压、低氧适应调节及并发症中可能发挥了重要作用。
Conclusion: Hypoxia induces elevated secretion of VEGF and the changes of VEGF may be related to hypoxic pulmonary hypertension, hypoxic adaptative regulation and complications of HAPC.
缺氧诱导因子1（HIF-1）是近年发现的调控细胞低氧适应性变化的重要转录因子。
Hypoxia-inducible factor-1(HIF-1), a newly discovered factor in recent years, is an important transcription factor which can control the cells′adaptive responses to hypoxia.
缺氧诱导因子- 1 (HIF - 1)是由低氧等诱导细胞产生的1种转录因子，能激活许多缺氧反应性基因的表达。
Hypoxia inducible factor-l (HIF-1), which can stimulate expression of hypoxia induced-responsed, is a kind of transcriptive factor.
缺氧诱导因子- 1 (HIF - 1)是由低氧等诱导细胞产生的1种转录因子，能激活许多缺氧反应性基因的表达。
Hypoxia inducible factor-l (HIF-1), which can stimulate expression of hypoxia induced-responsed, is a kind of transcriptive factor.
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