如果把药物撤掉,当休眠病毒苏醒过来的时候,它会迅速地再次感染所在的人体。
Take the drugs away, and when a dormant virus wakes up again it will rapidly reinfect the body it is in.
为了对付处于休眠状态的艾滋病毒,几名研究人员正在采取一种似乎有悖常理的做法。
To deal with dormant viruses several researchers are taking what sounds like a counterintuitive approach.
这种休眠细胞不会自己制造大量蛋白质,因此病毒无法介入蛋白质生产过程——它们就是借此繁殖的。
Such cells on sabbatical do not churn out many proteins of their own, so the virus cannot hijack the protein-manufacturing process—which is how it reproduces.
病毒产生休眠的原因之一就是病毒寄居的T细胞本身就是休眠状态。
One of the causes of viral dormancy is that the T-cell the virus resides in is itself in a resting state.
但该领域的许多研究人员认为与驻留在T细胞这样储存组织中的艾滋病毒相比,艾滋病复发的一个更重要原因是T细胞常处于休眠状态。
But many workers in the field think T-cell dormancy a more significant cause of relapse than HIV in such reservoir tissues.
“二甲胺四环素降低了病毒脱离休眠状态的感染T细胞的能力,”Szeto解释说。
"Minocycline reduces the capability of the virus to emerge from resting infected t cells," Szeto explains.
这并不是说感染了巨细胞病毒会自动引起脑肿瘤。这种存在于百分之八十人群中的病毒呈休眠状态。
It is not that catching cytomegalovirus automatically causes a brain tumour-the virus is found, inactive, in about 80% of the population.
研究人员通过这些测试发现SAHA将休眠艾滋病毒细胞的基因表达提高了五倍。
These tests have found that it increases the expression of dormant HIV genes fivefold.
它们没有休眠的形式,它们的基因比病毒的小得多。
They lack a dormant form and their genomes are much smaller than those of viruses .
这样的复制水平足以感染临近的T淋巴细胞,使休眠期记忆性T细胞中的病毒潜藏库不断得到扩充。
This level of replication sufficient to infection near the T-lymphocytes, so that a period of dormancy memory t cells in virus hidden library has been expanded.
所以对于研究人员最大的挑战是,如何使病毒处于“休眠”状态,同时使用鸡尾酒疗法降低病毒复制的速度。
So the biggest challenge for researchers is how the virus is in "sleep" state while using the cocktail therapy to reduce the speed of viral replication.
他的课题组在鼠身上实验,发现休眠的疱疹病毒强化了鼠的免疫系统,使其更不易受某些细菌的感染。
In mice, his team found that dormant herpesviruses revved up the immune system just enough to make the mice less susceptible to certain bacterial infections.
大部分被感染的记忆性T细胞因病毒或免疫系统的攻击而死亡,有一些会回到休眠状态。
Most of the infected memory T cells due to a virus or the immune system attacks and death, some will return to hibernation.
大部分被感染的记忆性T细胞因病毒或免疫系统的攻击而死亡,有一些会回到休眠状态。
Most of the infected memory T cells due to a virus or the immune system attacks and death, some will return to hibernation.
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