肾脏疾病对高原型排泄分数药物的代谢动力学影响较大。
Renal diseases produce greater effects on the kinetics of drugs with a high fraction excreted unchanged.
目的研究酮康唑对沙奎那韦的体外代谢和药物代谢动力学的影响。
Aim to investigate the effect of ketoconazole on the metabolism in vitro and pharmacokinetics of saquinavir.
短期和长期安全性评价和预测非常重要，同样重要的还有佐剂本身的药物代谢动力学评价。
Short-term and long-term safety evaluation and prediction are important, as is the evaluation of the pharmacokinetics of the adjuvant alone.
目的研究汉族健康志愿者单剂量静脉滴注盐酸头孢吡肟后的药物代谢动力学。
Objective To study the pharmacokinetics of cefepime after a single intravenous administration in Han healthy Chinese volunteers.
随着对苯的毒理、代谢动力学等领域研究的深入，低浓度苯对机体的影响已引起注意。
The effect of low benzene concentration for the organism has been noticed along with the advanced study on the toxicology, metabolic kinetics etc of benzene.
这些试验中的相关的药物代谢动力学和机械学的研究将会考虑到优化药物定量和监测。
Linked pharmacokinetic and mechanistic studies within these trials will allow for optimizing drug dosing and monitoring.
增加身体脂肪含量和减少全身含水量和肌肉数量，可以解释许多药物代谢动力学的变化。
Increased body fat and decreased total body water and muscle mass account for many of the pharmacokinetic changes.
本文研究了酸奶凝固过程中嗜热链球菌及保加利亚乳杆菌两种混合发酵菌的生长代谢动力学。
In this paper, growth and metabolic kinetics of Lactobacillus bulgricus and streptococcus thermophilus in forming yoghurt process were measured.
专家咨询和2002年6月GACVS的会议资料表明，乙基汞与甲基汞的药物代谢动力学情况是很不一样的。
Expert advice and data presented to the GACVS in June 2002 indicate that the pharmacokinetics of ethyl and methyl mercury are quite different.
采用草鱼生长激素夹心式酶联免疫吸附测定法（ELISA） ，研究了重组鲤生长激素（rcGH）在胡子鲶血浆中的代谢动力学。
Using the sandwich enzyme linked immunosorbent assay(ELISA) for grass carp growth hormone , plasma kinetics of rcGH in Clarias batrachus after administrations of rcGH were investigated.
摘要 ：本文简要综述了蟾毒它灵的相关研究进展，其研究主要集中在提取分离、抗肿瘤作用机理、药物代谢动力学、毒性及合成等方面。
Abstract : This paper reviews the research progress on bufotalin. It mainly focused on extraction and isolation, anti-tumor mechanism, pharmacokinetics, toxicity, synthetic and so on.
本文综述了右旋美托咪啶的药理学、药物代谢动力学及其在重症监护病室中的临床应用，包括对谵妄的防治、药物本身的安全性和其特殊的可唤醒镇静效应。
This article reviewed the pharmacology, pharmacokinetics and its application in ICU, including its application in prevention and control of delirium, drug safety and its arousal sedation effects.
虽然大脑代谢与血氧动力学的关系还没有完全理解，但可以认为运送更多的氧气需要更多的血流量。
More oxygen requires more blood flow, although the connection between cerebral metabolism and hemodynamics is not fully understood yet.
巴格列酮已经经过一系列临床前期药效药理学、安全药理学、药代动力学或毒性动力学和药物代谢研究的评估。
Balaglitazone has been evaluated in a series of preclinical efficacy pharmacology, safety pharmacology, pharmacokinetic/toxicokinetic, and drug metabolism studies.
目的通过了解血液乙醛代谢的动力学变化，为建立酒精中毒实验动物模型提供依据。
Objective To provide some evidence for establishing alcoholism experimental animal model by understanding the kinetic change of the rat blood acetaldehyde metabolism.
乳酸动力学的研究是对乳酸代谢动态平衡内在各种因素的综合。
The study of lactate dynamics is the synthesis of various internal factors during dynamic balances of lactate metabolism.
目的探讨原位肝移植(olt)术后早期血液动力学及氧代谢的变化。
Objective to investigate the changes in hemodynamics and oxygen metabolism during early period after orthotopic liver transplantation (OLT).
目的探讨良性听觉刺激对新生儿脑氧合代谢和脑血流动力学的影响。
Objective To study effects of benignant auditory stimulation(BAS) on cerebral oxygen metabolism and cerebral hematodynamics in neonates.
观察体肺循环血流动力学、冠状动脉血流量、心肌氧代谢及心肌静脉血乳酸、腺苷及内皮素浓度变化。
Then the cardiopulmonary hemodynamics, coronary flow, myocardial oxygen metabolism, and the concentrations of lactic acid, adenosine and endothelin of myocardial venous blood were measured.
目的探讨反比通气(IRV)对急性呼吸窘迫综合征(ARDS)绵羊血流动力学及氧代谢的影响。
Objective to observe the effect of inverse ratio ventilation (IRV) on hemodynamics and oxygen metabolism in sheep with acute respiratory distress syndrome (ARDS).
药物对映体结构特异性对局麻药药代动力学的各个过程都有着很大影响，包括药物的吸收、蛋白结合率、代谢等。
The enantiomer-specific structure of local anaesthetics has large impact on the pharmacokinetic process of these drugs, including absorption, protein-binding ratio, metabolism, and so on.
方法对大脑皮层功能活跃可引起的功能区代谢变化和血液动力学改变，以及这些改变对MR信号的影响进行了总结。
Methods the metabolic and hemodynamic changes induced by the functional activities in brain cortex and the relationship between these changes with the local MR signal were summarized.
目的探讨不同机械通气策略对急性肺损伤（ALI）患者血液、呼吸动力学和氧代谢的影响。
Objective To explore the effects of different ventilation tactics on pneumodynamics, hemodynamics and metabolism of oxygen in patients with acute lung injury(ALI).
目的：研究强的松、强的松龙在10名男性健康志愿者血浆及血中有核细胞内的可逆代谢药代动力学。
OBJECTIVE: To investigate reversible metabolic pharmacokinetics of prednisone and prednisolone in plasma and blood nucleated cells in 10 healthy male volunteers.
目的比较异丙酚和咪唑安定静脉复合麻醉对心脏瓣膜置换手术患者麻醉期血液动力学和氧代谢的影响。
Objective To compare the hemodynamic effects and oxygenation state of propofol and midazolam combined with fentanyl for total intravenous anesthesia in patients undergoing cardiac valve replacement.
目的：建立SPE—HPLC法测定人血浆中喹那普利及其代谢产物喹那普利拉的浓度，以研究喹那普利及喹那普利拉在健康志愿者中的药代动力学和相对生物利用度。
Objective:To establish a SPE-HPLC method for the determination of quinapril and its active metabolite quinaprilat in human plasma and to evaluate their pharmacokinetics and relative bioavailability.
主要代谢产物去甲丙咪嗪药时曲线符合一室线性动力学。
The concentration-time curve of desipramine, the major metabolite of imipramine, fitted in with a one-compartment kinetic model.
主要代谢产物去甲丙咪嗪药时曲线符合一室线性动力学。
The concentration-time curve of desipramine, the major metabolite of imipramine, fitted in with a one-compartment kinetic model.
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