大部分的遗传毒性致癌物是与DNA结合的亲电子试剂，它们直接与DNA相互作用，形成共价键，从而形成DNA -致癌物复合体，或称之为dna加合物。
Most of Genotoxic carcinogens are electrophiles that bind with DNA, and they interact directly with DNA and form covalent bond, resulting in DNA-carcinogen complexes, or DNA adducts.
探讨碱性、溶剂极性、离去基团、吸电子基团、亲核试剂的亲核性对反应影响。
There are impact factor to be discussed such as solvent polarity, nucleofuge, attract electron group the nunucleophilicity of nucleophilic reagent.
并且对亲核试剂的体积效应、溶剂效应对亲核性影响，底物上吸电子基团的数目、吸电子能力对亲电性的影响，以及亲核取代反应的发生部位受哪些因素影响进行探讨。
At the same time, discuss about the impact factor to nucleophilicity such as the number of attract electron group, ability of attract electron and the nucleophilic substitution reaction part.
并且对亲核试剂的体积效应、溶剂效应对亲核性影响，底物上吸电子基团的数目、吸电子能力对亲电性的影响，以及亲核取代反应的发生部位受哪些因素影响进行探讨。
At the same time, discuss about the impact factor to nucleophilicity such as the number of attract electron group, ability of attract electron and the nucleophilic substitution reaction part.
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