在乙腈溶剂中,碳酸钾存在下,双咪唑啉和1,2-二溴乙烷进行扩环反应,得到环状中间体一溴盐,产率78。
The reaction of bis-imidazoline with 1,2-dibromoethane and potassium carbonate in acetonitrile provided monobromide salt with a yield of 78.
以1,3-二甲基金刚烷为原料,经溴化、乙腈和硫酸的作用下乙酰胺基化、水解、成盐等反应及改进的后处理方法得到盐酸美金刚,总收率6 7。8%。
Memantine hydrochloride was synthesized from 1,3 dimethyladamantane by bromination, acetamidation with acetonitrile in sulfuric acid and hydrolysis with an overall yield of 67.8%.
以1,3-二甲基金刚烷为原料,经溴化、乙腈和硫酸的作用下乙酰胺基化、水解、成盐等反应及改进的后处理方法得到盐酸美金刚,总收率6 7。8%。
Memantine hydrochloride was synthesized from 1,3 dimethyladamantane by bromination, acetamidation with acetonitrile in sulfuric acid and hydrolysis with an overall yield of 67.8%.
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