研究背景多发性硬化一般被认为是以中枢神经系统炎性脱髓鞘疾病为特征的自身免疫性疾病。
Background: Multiple sclerosis is a characterized demyelinating disease of the CNS and postulated to be a autoimmune disease.
实验性自身免疫性脑脊髓炎(eae)是一种免疫细胞介导的以中枢神经系统白质损坏为特征的自身免疫性疾病。
Experimental allergic encephalomyelitis (EAE) is an immune disease, whose character is the damage of white matter of nervous system mediated by immunocyte.
同时他还说：“这个研究结果强调了这样一个事实——血脑屏障的通透性改变是发生象实验性变应性脑脊髓炎(一种多发性硬化病的动物模型)这类中枢神经系统感染性疾病的重要因素。”
"This puts an emphasis on the fact that blood brain permeability changes are an important aspect of the development of a CNS inflammatory disease like EAE, an animal model of MS," he says.
也公开了所述化合物在治疗炎性疾病和其它与细胞因子水平升高有关的疾病，以及中枢神经系统(CNS)疾病中的用途。
Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
也公开了所述化合物在治疗炎性疾病和其它与细胞因子水平升高有关的疾病，以及中枢神经系统(CNS)疾病中的用途。
Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
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