实验室中以患乳腺癌的老鼠为试验对象，研究者发现联合用药可以抑制癌症干细胞，而癌症干细胞是肿瘤扩增的驱动因素。
In lab tests using mice with breast cancer, researchers found that the drug combination suppressed the cancer stem cells thought to drive tumor progression.
Wicha实验室作为小组的一部分在2003年首先在人乳腺癌中识别出干细胞。
Wicha's lab was part of the team that first identified stem cells in human breast cancer in 2003.
目的了解乳腺癌细胞系mcf - 7中是否存在乳腺癌干细胞，以及在不同的培养条件下，干细胞池的变化情况。
Objective To know if MCF-7 breast cancer cell line has breast cancer stem cell, and change of stem cell pool in diverse incubation circumstance.
结论：乳腺癌4t 1细胞可在含多种生长因子的SFM中悬浮生长并形成细胞球，4t1细胞中含有的乳腺癌干细胞样细胞可通过SFM培养法富集。
Conclusion: 4t1 cells can grow and form spheres in serum-free suspension medium containing growth factor, and they contain breast cancer stem-like cells, which can be enriched when cultured in SFM.
结论：乳腺癌4t 1细胞可在含多种生长因子的SFM中悬浮生长并形成细胞球，4t1细胞中含有的乳腺癌干细胞样细胞可通过SFM培养法富集。
Conclusion: 4t1 cells can grow and form spheres in serum-free suspension medium containing growth factor, and they contain breast cancer stem-like cells, which can be enriched when cultured in SFM.
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