目的制备具有良好喷雾特性的丙酸氟替卡松鼻喷雾剂。
AIM To prepare the fluticasone propionate nasal spray of good spray characteristics.
在早期先行性实验中，研究者用口服较稠的布地奈德成功地治疗了两位不能使用丙酸氟替卡松的病人。
In an earlier, pilot study, researchers used oral viscous budesonide to successfully treat two patients who had been unable to utilize fluticasone propionate.
盐酸氮卓斯汀组和丙酸氟替卡松组的总有效率分别为83.78%和90.00%，两组差异无统计学意义（P>0.05）。
There was no significant difference between the total response rate of azelastine hydrochloride and of fluticasone propionate(83.78% vs 90.00%, P>0.05).
以双氟美松为原料，经氧化、酯化、酰化、醇解和氟甲基化反应制得氟替卡松丙酸酯（1），总收率60。
Fluticason propionate(1) in overall yield of 60.1% was synthesized from Flumethasone by oxidation, esterification, acylation, alcoholysis and fluoromethylation.
以双氟美松为原料，经氧化、酯化、酰化、醇解和氟甲基化反应制得氟替卡松丙酸酯（1），总收率60。
Fluticason propionate(1) in overall yield of 60.1% was synthesized from Flumethasone by oxidation, esterification, acylation, alcoholysis and fluoromethylation.
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