已有研究表明丙型肝炎病毒进入细胞内需要紧密连接蛋白克劳丁-1（CLDN1）。
The tight junction protein claudin-1 (CLDN1) has been shown to be required for entry of HCV into the cell.
目的：构建丙型肝炎病毒(HCV)全长及3种不同缺失突变的核心蛋白基因的原核表达载体，并在大肠杆菌中表达。
AIM: to construct the recombinant plasmids expressing full-length HCV core protein gene and 3 different deletion mutated hepatitis core protein genes and to express them in E. coli.
紧密连接蛋白克劳丁-1单克隆抗体能够有效地抑制大多数基因型丙型肝炎病毒感染和自患者分离的高度突变的丙型肝炎病毒准种感染。
The monoclonal antibodies against CLDN1 efficiently inhibited infection by HCV of all major genotypes as well as highly variable HCV quasispecies isolated from individual patients.
利用毕赤酵母系统表达具有催化活性的丙型肝炎病毒（HCV）NS3蛋白酶。
Non-structural protein 3(NS3) of hepatitis C virus (HCV), the serine protease, is a key functional protein, which is responsible for the processing of HCV polyprotein.
结果：综述了丙型肝炎病毒核心蛋白t、b细胞表位及对细胞周期的影响。
Results: There are some t and B cell epitopes on HCV core protein, and HCV core protein can affect cell cycle.
目的应用多抗原肽（MAP）研究丙型肝炎病毒包膜糖蛋白高变区1（HVR1）的抗原性。
Objective To study the immunogenicity of multiple antigen peptide (MAP) corresponding to the hypervariable region 1(HVR1) within the putative envelope glycoprotein E2/NS1 of hepatitis C virus(HCV).
目的应用多抗原肽（MAP）研究丙型肝炎病毒包膜糖蛋白高变区1（HVR1）的抗原性。
Objective To study the immunogenicity of multiple antigen peptide (MAP) corresponding to the hypervariable region 1(HVR1) within the putative envelope glycoprotein E2/NS1 of hepatitis C virus(HCV).
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