目的：初步探讨口腔白斑的重度上皮异常增生及癌变与吸烟的关系。
Objective: To study the relationship between smoking and malignant transformation of oral leukoplakia.
OLK组伴重度上皮异常增生组织中opn阳性细胞数量明显增多且分布于上皮全层。
In OLK patients with sever epithelium dysplasia, the Numbers of OPN positive cells increased obviously and the positive cells spread the whole epithelial cell stratum.
结果CK19表达于有上皮异常增生的复层鳞状上皮基底上层和口腔鳞癌尤其是低分化鳞癌的癌细胞中。
Results CK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor differentiated cancerous cells.
结果：68例患者中，7例(10.3%)术中冷冻切片证实有一侧输尿管残端异常，其中6例为恶性肿瘤细胞侵润，1例为移行上皮不典型增生。
Results: 7 of 68 patients (10.3%) had evidence of ureteral abnormality on frozen section, 1 of 7 was mild atypia, other 6 was carcinoma in situ involving the distal ureter.
结果9份标本d -环共有15个突变点，增生性导管上皮细胞d -环至少存在一个以上异常点。
Results a total number of 15 alterations existed in D-loops of 9 samples. D-loops in ductal hyperplasia epithelial cells displayed at least one variants.
方法采用免疫组织化学s - P法检测8例口腔粘膜上皮单纯增生、25例异常增生、52例鳞癌中P 15的表达。
Methods Immunohistochemical method (S-P) was used to detect the P15 expression in 8 cases of simple hyperplasia epithelium, 25 cases of dysplasia epithelium and 52 cases of OSCC.
方法采用免疫组织化学s - P法检测8例口腔粘膜上皮单纯增生、25例异常增生、52例鳞癌中P 15的表达。
Methods Immunohistochemical method (S-P) was used to detect the P15 expression in 8 cases of simple hyperplasia epithelium, 25 cases of dysplasia epithelium and 52 cases of OSCC.
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