随后人GRP94启动子克隆了荧光素酶基因上游区且缺氧环境中活性增强。
The human GRP94 promoter was then cloned upstream of the luciferase gene and showed enhanced activity in hypoxic conditions.
方法:检索并分析釉原蛋白基因的上游调控序列。
METHODS: The upstream regulation sequences of amelogenin gene were retrieved and analyzed.
目的探讨血清对白念珠菌菌相转换特异基因HYR1上游启动子活性的影响。
Objective To study the effect of serum on promoter activity of Candida albicans yeast-hyphal regulational gene(HYR1).
载体经修改后包括带有一合成的剪接供体的一个异种内含子, 此供体经促性腺激素a亚单位基因(含有一个剪接受体)的内含子A中某片段的上游改造。
The vector was modified to include a heterologous intron with a synthetic splice donor engineered upstream of a fragment from intron A of the gonadotropin a subunit gene(containing a splice acceptor).
方法:将基因内翻译起始序列合成后克隆到上游含有起始密码和无起始密码的报告质粒中,研究表达水平的差异。
Methods:One of the three internal translation initiation region(TIR) was chemically synthesized and cloned into the report plasmid, and the expression of the report gene was studied.
IRX1基因转录起始点上游存在高甲基化结构基础。
There is a hypermethylation sequential basis in the upstream region from the transcriptional start site of IRX1 gene.
目的探讨白念珠菌耐药基因CDR1基因上游调控序列对氟康唑耐药的影响。
Objective To appraise the relationship between fluconazole resistance and expression of the CDR1 gene upstream regulation sequence.
结论PASG基因作为上游调控基因,通过改变基因组甲基化水平调控下游一系列细胞增殖分化相关基因表达。
Conclusions AS an upstream regulator, PASG can regulate expression of a series of cell proliferation, differentiation relevant downstream genes through changing methylation levels of genomic DNA.
所克隆的奶山羊blg基因调控区与山羊blg伪基因显著不同,其同源性仅为83 %(上游调控区)和88%(下游调控区)。
The dairy goat gene differed significantly from goat BLG pseudo gene with a homology of only 83% (upstream region) and 88% (downstream region), respectively.
Vyse博士及其同事报告称,统计分析确定“没有一个基因型变异与TNFSF4上游区的这种联系有关” 。
Statistical analysis established that "no single genotyped variant is responsible for the association in the upstream region of TNFSF4, " Dr. Vyse and colleagues report.
因此选择对基因的表达具有重要功能的外显子1和其上游的调控区及下游外显子内含子交界区序列通过直接测序法进行SNP筛查,并进一步分析多态位点与病窦的关联性。
Therefore the other aim of our study is to discover SNPs of HCN4 exon 1, including the regulatory sequence and exon-intron boundary of it, which plays an importable role of channel function.
因此选择对基因的表达具有重要功能的外显子1和其上游的调控区及下游外显子内含子交界区序列通过直接测序法进行SNP筛查,并进一步分析多态位点与病窦的关联性。
Therefore the other aim of our study is to discover SNPs of HCN4 exon 1, including the regulatory sequence and exon-intron boundary of it, which plays an importable role of channel function.
应用推荐