Ashar Aziz, founder of FireEye, recognized early on that custom malware, zerodaythreats, and drive by downloads could all slip by common defenses that most organizations have deployed (firewals, IPS, AV).
While some customers use this to overcome problems they have with enforcing vulnerability and patch management policies it is a cumbersome technology that does nothing to address new threats, zeroday vulnerabilities, or insider attacks.