In part, the very public style of Ms Bonino's work is determined by the substance of it.

ECONOMIST: Emma Bonino, Europe��s commissioner for the future

Developing a substance that would work reliably in potentially extreme conditions and remain stable over the life of the material was also a challenge.

CNN: The emerging world of self-healing materials

Images and gestures can and do work, but only if matched by substance.

CNN: Behind the BJP's Mask

The community coalition has done great work in Newtown to reduce underage drinking and substance use.

WHITEHOUSE: Our Top Stories

They work by inhibiting prostaglandin, a hormone-like substance that plays a part in signalling pain to the brain.

BBC: Pregnant women warned off painkillers

Prof Peter Higgs developed a theory of how other sub-atomic particles came to have substance, or mass, and published his work in 1964.

BBC: Science correspondent, BBC News

Freeze-drying the mixture wouldn't work because it would come out as a clumpy, cakelike substance.

FORBES: The Impossible Made Possible

Further trials will examine questions such as how the vaccine works in combination with the seasonal flu vaccine and whether including an adjutant, a substance that boosts the immune response to vaccines, can make it work better at lower doses.

CNN: U.S. trials for H1N1 vaccine announced

This doesn't seem to be looking at the substance of the Messham allegations over the weekend, but about the remit and work of the original Waterhouse inquiry.

BBC: History back in the headlines

The long-term aim of Welsh football's top brass is for Flynn to work alongside Ryan Giggs, Welsh football's most famous export, in a perfect synergy of footballing style and substance.

BBC: Brian Flynn - the small man in Wales' big job