The New York-based drug giant says last night it received news that in a study, sponsored by the National Cancer Institute, on using Celebrex to prevent cancerous colon polyps, the drug more than doubled the risk of heart attacks and strokes. (The risk showed up with the highest dose of Celebrex.) That study, called the APC trial, has been halted.
For that reason, some physicians treat patients with the highest dose of Lipitor possible and then add Zetia, thereby getting as much power from Lipitor as possible.
Marta Schulman, chair of the American College of Radiology Pediatric Imaging Commission, said the study adds to the impetus that patients should be scanned only when necessary and with the lowest dose of radiation possible.
Another study, called ASAP, conducted by some of the same experts who ran ENHANCE, compared the top dose of 80 milligrams of Pfizer's Lipitor with the second-highest dose of Zocor.
With the development of Suboxone Film, the company was able to introduce child resistant, unit-dose packaging with the same active ingredient before it was able to identify and resolve the packaging issues experienced with Suboxone Tablets.
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But 13% of patients on the high-dose group discontinued because of side effects during the first year, compared with 9% in the lower-dose group and 7.2% on placebo.
As it turned out, 160 of the drugs came through the vaporization process with sufficient dose quantity and purity and the right particle size.
We will work with the FDA to determine the best dose for approval.
Nevertheless, while the primary endpoint in the PRE-SURGE 2 trial does not appear to have any dose response, as you noted, the endpoints in PRE-SURGE 1 and the secondary endpoints in PRE-SURGE 2 appear to trend slightly better with the 160 mg dose.
The absence of the 80-mg dose may raise another fear with investors: that the 40-mg dose would also not reach the U.S. market.
The study, funded by Pfizer (nyse: PFE - news - people ) and called Treating New Targets, or TNT, showed that the top dose of Lipitor decreased the risk of heart attacks and strokes in people with stable heart disease, compared to the lowest dose of the same drug.
The drug didn't help those with moderate cases, but at the highest dose it did tend to help those with mild symptoms.
The film doesn't romanticize the ordeal: It is dark, but with a healthy dose of the absurd.
To pull out the most relevant number from that: the decline in distance walked among patients treated with a high dose of the drug was about a tenth as much as for those who were on the low dose.
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Since the vaccination programme was introduced in 2008, 89% of Year 9 girls received the first dose, with 85% and 83% receiving the second and third.
Most importantly, the order said, examiners at the U.S. Patent and Trademark Office determined that the information at issue was irrelevant to patentability, saying it dealt with tests of the median lethal dose of the drug, not the much lower doses used by consumers.
Naturally, we're taking this with more than the usual dose of skepticism, but like Fox Mulder, we want to believe.
The combination of dissatisfied fans and mutinous developers is leavened with a dose of nostalgia for the good old days.
In an effort to recapture the glory years, they made over the roster with a dose of heavy spending this winter.
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There is no plan to develop FDCs with the sitagliptin 25 mg dose as use of this dose is quite low.
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You might want to discuss with your doctor raising the dose to at least 10 mg three times a day or discontinuing it.
There is also no plan to develop FDCs with the simvastatin 5 mg dose as use of this dose is quite low as well.
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According to Lieberman, the investigators approached the makers of all the drugs being used in CATIE with proposed dose ranges that went above what the U.S. Food and Drug Administration had approved.
It seems unlikely that a smartphone application, as opposed to more tried-and-tested methods like vaccination or a face mask, could help you avoid going down with a dose of the flu this winter.
This is good, because for all the depth of customization, the game needs more varied environments and a healthy dose of tinkering with the balance.
The band laced its music with a heavy dose of good humor to complement the intricate musicianship, but could never move beyond cult status internationally.
The studies were done with rabbits, which were given the same dose of the active ingredient SPL7013 that is found in VivaGel.
Their exams are over, the sun is shining, and there are no lectures to interfere with a daily dose of Neighbours on the telly.
If this ends up being the proverbial nail in the coffin for any of these banks it will come with a heavy dose of painful iron because the U.S. government that bailed them out just three years ago may send them back on the path toward failure.
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